SCOPe 2.08: Domain d2hwzl2: 2hwz L:107-213

Lineage for d2hwzl2 (2hwz L:107-213)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (24 proteins)

6. Protein Immunoglobulin light chain kappa constant domain, CL-kappa [88566] (4 species)

7. Species Human (Homo sapiens) [TaxId:9606] [88569] (147 PDB entries)
   including humanized antibodies (chimeric proteins with human constant domains)
   SQ NA # humanized antibody ! Uniprot P01834 # KAC_HUMAN Ig kappa chain C region ! SQ P01834 # KAC_HUMAN Ig kappa chain C region. ! SQ NA # engineered antibody

8. Domain d2hwzl2: 2hwz L:107-213 [147430]
   Other proteins in same PDB: d2hwzl1
   automatically matched to d1dqdl2

Details for d2hwzl2

PDB Entry: 2hwz, 1.8 Å

PDB Description: fab fragment of humanized anti-viral antibody medi-493 (synagis tm)

PDB Compounds: (L:) Immunoglobulin Fab light chain

SCOPe Domain Sequences for d2hwzl2:

Sequence; same for both SEQRES and ATOM records:

>d2hwzl2 b.1.1.2 (L:107-213) Immunoglobulin light chain kappa constant domain, CL-kappa {Human (Homo sapiens) [TaxId: 9606]}
rtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqd
skdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec

Timeline for d2hwzl2:

• d2hwzl2 first appeared in SCOP 1.75
  
• d2hwzl2 appears in SCOPe 2.07