Lineage for d2ciba1 (2cib A:5-449)

  1. Root: SCOP 1.75
  2. 758332Class a: All alpha proteins [46456] (284 folds)
  3. 774742Fold a.104: Cytochrome P450 [48263] (1 superfamily)
    multihelical
  4. 774743Superfamily a.104.1: Cytochrome P450 [48264] (1 family) (S)
  5. 774744Family a.104.1.1: Cytochrome P450 [48265] (22 proteins)
  6. 774791Protein Cytochrome p450 14 alpha-sterol demethylase (cyp51) [48276] (1 species)
  7. 774792Species Mycobacterium tuberculosis [TaxId:1773] [48277] (9 PDB entries)
    Uniprot P0A512 P77901
  8. 774793Domain d2ciba1: 2cib A:5-449 [146398]
    automatically matched to d1x8va_
    complexed with cm6, hem; mutant

Details for d2ciba1

PDB Entry: 2cib (more details), 1.5 Å

PDB Description: high throughput screening and x-ray crystallography assisted evaluation of small molecule scaffolds for cyp51 inhibitors
PDB Compounds: (A:) cytochrome p450 51

SCOP Domain Sequences for d2ciba1:

Sequence, based on SEQRES records: (download)

>d2ciba1 a.104.1.1 (A:5-449) Cytochrome p450 14 alpha-sterol demethylase (cyp51) {Mycobacterium tuberculosis [TaxId: 1773]}
alprvsgghdehghleefrtdpiglmqrvrdelgdvgtfqlagkqvvllsgshanefffr
agdddldqakaypfmtpifgegvvfdasperrkemlhnaalrgeqmkghaatiedqvrrm
iadwgeageidlldffaeltiytssacligkkfrdqldgrfaklyhelergtdplayvdp
ylpiesfrrrdearnglvalvadimngrianpptdksdrdmldvliavkaetgtprfsad
eitgmfismmfaghhtssgtaswtlielmrhrdayaavideldelygdgrsvsfhalrqi
pqlenvlketlrlhppliilmrvakgefevqghrihegdlvaaspaisnripedfpdphd
fvparyeqprqedllnrwtwipfgagrhrcvgaafaimqikaifsvllreyefemaqppe
syrndhskmvvqlaqpaavryrrrt

Sequence, based on observed residues (ATOM records): (download)

>d2ciba1 a.104.1.1 (A:5-449) Cytochrome p450 14 alpha-sterol demethylase (cyp51) {Mycobacterium tuberculosis [TaxId: 1773]}
alprvsgghdehghleefrtdpiglmqrvrdelgdvgtfqlagkqvvllsgshanefffr
agdddldqakaypfmtpifglrgeqmkghaatiedqvrrmiadwgeageidlldffaelt
iytssacligkkfrdqldgrfaklyhelergtdplayvdpylpiesfrrrdearnglval
vadimngrianpdrdmldvliavkaetgtprfsadeitgmfismmfaghhtssgtaswtl
ielmrhrdayaavideldelygdgrsvsfhalrqipqlenvlketlrlhppliilmrvak
gefevqghrihegdlvaaspaisnripedfpdphdfvparyeqprqedllnrwtwipfga
grhrcvgaafaimqikaifsvllreyefemaqppesyrndhskmvvqlaqpaavryrrrt

SCOP Domain Coordinates for d2ciba1:

Click to download the PDB-style file with coordinates for d2ciba1.
(The format of our PDB-style files is described here.)

Timeline for d2ciba1: