SCOPe 2.02: Domain d2izva2: 2izv A:274-385

Lineage for d2izva2 (2izv A:274-385)

1. Root: SCOPe 2.02

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.93: SH2-like [55549] (1 superfamily)
   3 layers: a/b/a; antiparallel beta-sheet of 5 strands is flaked by two helices

4. Superfamily d.93.1: SH2 domain [55550] (2 families)

5. Family d.93.1.1: SH2 domain [55551] (35 proteins)
   Pfam PF00017

6. Protein Suppressor of cytokine signaling 4, SOCS-4 [160564] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [160565] (1 PDB entry)
   Uniprot Q8WXH5 274-385

8. Domain d2izva2: 2izv A:274-385 [145556]
   Other proteins in same PDB: d2izva1, d2izvb_, d2izvc_
   complexed with cl, edo, na

Details for d2izva2

PDB Entry: 2izv, 2.55 Å

PDB Description: crystal structure of socs-4 in complex with elongin-b and elongin-c at 2.55a resolution

PDB Compounds: (A:) suppressor of cytokine signaling 4

SCOPe Domain Sequences for d2izva2:

Sequence; same for both SEQRES and ATOM records:

>d2izva2 d.93.1.1 (A:274-385) Suppressor of cytokine signaling 4, SOCS-4 {Human (Homo sapiens) [TaxId: 9606]}
lvpdllqinnnpcywgvmdkyaaeallegkpegtfllrdsaqedylfsvsfrrysrslha
rieqwnhnfsfdahdpcvfhspditgllehykdpsacmffepllstplirtf

Timeline for d2izva2:

• d2izva2 first appeared in SCOP 1.75
  
• d2izva2 appears in SCOPe 2.01
  
• d2izva2 appears in SCOPe 2.03
  
• d2izva2 appears in the current release, SCOPe 2.08