SCOPe 2.05: Domain d2i5ys1: 2i5y S:2-27

Lineage for d2i5ys1 (2i5y S:2-27)

1. Root: SCOPe 2.05

2. Class k: Designed proteins [58788] (44 folds)

3. Fold k.23: Scorpion toxin-based designs [58917] (1 superfamily)

4. Superfamily k.23.1: Scorpion toxin-based designs [58918] (2 families)

5. Family k.23.1.2: Mini-protein reproducing the core of the CD4 surface [58922] (1 protein)

6. Protein Mini-protein reproducing the core of the CD4 surface [58923] (1 species)
   interacting with the hiv-1 envelope glycoprotein

7. Species Synthetic [58924] (5 PDB entries)

8. Domain d2i5ys1: 2i5y S:2-27 [145505]
   Other proteins in same PDB: d2i5yg_, d2i5yh1, d2i5yh2, d2i5yl1, d2i5yl2, d2i5yp_, d2i5yq1, d2i5yq2, d2i5yr1, d2i5yr2
   complexed with nag, ndg

Details for d2i5ys1

PDB Entry: 2i5y, 2.2 Å

PDB Description: crystal structure of cd4m47, a scorpion-toxin mimic of cd4, in complex with hiv-1 yu2 gp120 envelope glycoprotein and anti-hiv-1 antibody 17b

PDB Compounds: (S:) cd4m47, scorpion-toxin mimic of cd4

SCOPe Domain Sequences for d2i5ys1:

Sequence; same for both SEQRES and ATOM records:

>d2i5ys1 k.23.1.2 (S:2-27) Mini-protein reproducing the core of the CD4 surface {Synthetic}
nlhfcqlrckslgllgrcaptfcacx

Timeline for d2i5ys1:

• d2i5ys1 first appeared in SCOP 1.75
  
• d2i5ys1 appears in SCOPe 2.04
  
• d2i5ys1 appears in SCOPe 2.06
  
• d2i5ys1 appears in the current release, SCOPe 2.08