SCOPe 2.06: Domain d2fjub1: 2fju B:142-311

Lineage for d2fjub1 (2fju B:142-311)

1. Root: SCOPe 2.06

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.39: EF Hand-like [47472] (4 superfamilies)
   core: 4 helices; array of 2 hairpins, opened

4. Superfamily a.39.1: EF-hand [47473] (12 families)
   Duplication: consists of two EF-hand units: each is made of two helices connected with calcium-binding loop

5. Family a.39.1.7: EF-hand modules in multidomain proteins [47547] (9 proteins)

6. Protein Phospholipase C-beta-2 [158478] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [158479] (2 PDB entries)
   Uniprot Q00722 142-311

8. Domain d2fjub1: 2fju B:142-311 [145170]
   Other proteins in same PDB: d2fjua_, d2fjub2, d2fjub3, d2fjub4
   complexed with ca, gsp, mg

Details for d2fjub1

PDB Entry: 2fju, 2.2 Å

PDB Description: Activated Rac1 bound to its effector phospholipase C beta 2

PDB Compounds: (B:) 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 2

SCOPe Domain Sequences for d2fjub1:

Sequence, based on SEQRES records:

>d2fjub1 a.39.1.7 (B:142-311) Phospholipase C-beta-2 {Human (Homo sapiens) [TaxId: 9606]}
asrstfldkilvklkmqlnsegkipvknffqmfpadrkrveaalsachlpkgkndainpe
dfpepvyksflmslcprpeideiftsyhakakpymtkehltkfinqkqrdsrlnsllfpp
arpdqvqglidkyepsginaqrgqlspegmvwflcgpensvlaqdklllh

Sequence, based on observed residues (ATOM records):

>d2fjub1 a.39.1.7 (B:142-311) Phospholipase C-beta-2 {Human (Homo sapiens) [TaxId: 9606]}
asrstfldkilvklkmqlnsegkipvknffqmfpadrkrveaalsachlpkgkndainpe
dfpepvyksflmslcprpeideiftsymtkehltkfinqkqrdqglidkyepsgqlspeg
mvwflcgpensvlaqdklllh

Timeline for d2fjub1:

• d2fjub1 first appeared in SCOP 1.75
  
• d2fjub1 appears in SCOPe 2.05
  
• d2fjub1 appears in SCOPe 2.07
  
• d2fjub1 appears in the current release, SCOPe 2.08