SCOPe 2.06: Protein: Glutaminyl-peptide cyclotransferase, QPCT

Lineage for Protein: Glutaminyl-peptide cyclotransferase, QPCT

Root: SCOPe 2.06
Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
Fold c.56: Phosphorylase/hydrolase-like [53162] (8 superfamilies)
core: 3 layers, a/b/a ; mixed sheet of 5 strands: order 21354; strand 4 is antiparallel to the rest; contains crossover loops
Superfamily c.56.5: Zn-dependent exopeptidases [53187] (10 families)
core: mixed beta-sheet of 8 strands, order 12435867; strands 2, 6 & 7 are antiparallel to the rest
Family c.56.5.8: Glutaminyl-peptide cyclotransferase-like [142532] (1 protein)
part of Pfam PF04389
Protein Glutaminyl-peptide cyclotransferase, QPCT [142533] (2 species)
Glutaminyl cyclase

Species:

Human (Homo sapiens) [TaxId:9606] [142534] (22 PDB entries)
Uniprot Q16769 33-361
1. Domains for 2afm:
  1. Domain d2afma1: 2afm A:33-361 [126698]
    complexed with so4, zn
  2. Domain d2afmb_: 2afm B: [126699]
    automated match to d2afma1
    complexed with so4, zn
2. Domains for 2afo:
  1. Domain d2afoa_: 2afo A: [126700]
    automated match to d2afma1
    complexed with so4, zn
  2. Domain d2afob_: 2afo B: [126701]
    automated match to d2afma1
    complexed with so4, zn
3. Domains for 2afs:
  1. Domain d2afsa1: 2afs A:33-361 [126702]
    complexed with so4, zn; mutant
  2. Domain d2afsb_: 2afs B: [126703]
    automated match to d2afma1
    complexed with so4, zn; mutant
4. Domains for 2afu:
  1. Domain d2afua1: 2afu A:33-361 [126705]
    complexed with bgt, zn
  2. Domain d2afub_: 2afu B: [126706]
    automated match to d2afma1
    complexed with bgt, zn
5. Domains for 2afw:
  1. Domain d2afwa_: 2afw A: [126707]
    automated match to d2afma1
    complexed with ahn, so4, zn
  2. Domain d2afwb_: 2afw B: [126708]
    automated match to d2afma1
    complexed with ahn, so4, zn
6. Domains for 2afx:
  1. Domain d2afxa_: 2afx A: [126709]
    automated match to d2afma1
    complexed with 1bn, so4, zn
  2. Domain d2afxb_: 2afx B: [126710]
    automated match to d2afma1
    complexed with 1bn, so4, zn
7. Domains for 2afz:
  1. Domain d2afza_: 2afz A: [126712]
    automated match to d2afma1
    complexed with nvi, so4, zn
  2. Domain d2afzb_: 2afz B: [126713]
    automated match to d2afma1
    complexed with nvi, so4, zn
8. Domains for 2zed:
  1. Domain d2zeda_: 2zed A: [171173]
    automated match to d2afma1
    complexed with so4, zn; mutant
  2. Domain d2zedb_: 2zed B: [171174]
    automated match to d2afma1
    complexed with so4, zn; mutant
9. Domains for 2zee:
  1. Domain d2zeea_: 2zee A: [171175]
    automated match to d2afma1
    complexed with so4, zn; mutant
  2. Domain d2zeeb_: 2zee B: [171176]
    automated match to d2afma1
    complexed with so4, zn; mutant
10. Domains for 2zef:
  1. Domain d2zefa_: 2zef A: [171177]
    automated match to d2afma1
    complexed with so4, zn; mutant
  2. Domain d2zefb_: 2zef B: [171178]
    automated match to d2afma1
    complexed with so4, zn; mutant
11. Domains for 2zeg:
  1. Domain d2zega_: 2zeg A: [171179]
    automated match to d2afma1
    complexed with imd, so4, zn; mutant
  2. Domain d2zegb_: 2zeg B: [171180]
    automated match to d2afma1
    complexed with imd, so4, zn; mutant
12. Domains for 2zeh:
  1. Domain d2zeha_: 2zeh A: [154403]
    automated match to d2afma1
    complexed with so4, zn; mutant
  2. Domain d2zehb_: 2zeh B: [154404]
    automated match to d2afma1
    complexed with so4, zn; mutant
13. Domains for 2zel:
  1. Domain d2zela_: 2zel A: [171181]
    automated match to d2afma1
    complexed with so4, zn; mutant
  2. Domain d2zelb_: 2zel B: [171182]
    automated match to d2afma1
    complexed with so4, zn; mutant
14. Domains for 2zem:
  1. Domain d2zema_: 2zem A: [171183]
    automated match to d2afma1
    complexed with so4, zn; mutant
  2. Domain d2zemb_: 2zem B: [171184]
    automated match to d2afma1
    complexed with so4, zn; mutant
15. Domains for 2zen:
  1. Domain d2zena_: 2zen A: [171185]
    automated match to d2afma1
    complexed with so4, zn; mutant
  2. Domain d2zenb_: 2zen B: [171186]
    automated match to d2afma1
    complexed with so4, zn; mutant
16. Domains for 2zeo:
  1. Domain d2zeoa_: 2zeo A: [171187]
    automated match to d2afma1
    complexed with so4, zn; mutant
  2. Domain d2zeob_: 2zeo B: [171188]
    automated match to d2afma1
    complexed with so4, zn; mutant
17. Domains for 2zep:
  1. Domain d2zepa_: 2zep A: [171189]
    automated match to d2afma1
    complexed with so4, zn; mutant
  2. Domain d2zepb_: 2zep B: [171190]
    automated match to d2afma1
    complexed with so4, zn; mutant
18. Domains for 3pbb:
  1. Domain d3pbba_: 3pbb A: [183631]
    automated match to d2afma1
    complexed with pbd, zn
  2. Domain d3pbbb_: 3pbb B: [183632]
    automated match to d2afma1
    complexed with pbd, zn
19. Domains for 3pbe:
  1. Domain d3pbea_: 3pbe A: [183634]
    automated match to d2afma1
    complexed with so4, zn; mutant
  2. Domain d3pbeb_: 3pbe B: [183635]
    automated match to d2afma1
    complexed with so4, zn; mutant
20. Domain for 3si0:
  - Domain d3si0a_: 3si0 A: [185407]
    automated match to d2afma1
    complexed with cl, imd, zn
21. Domains for 4yu9:
  1. Domain d4yu9a_: 4yu9 A: [275753]
    automated match to d2zela_
    complexed with edo, so4, zn; mutant
  2. Domain d4yu9b_: 4yu9 B: [275752]
    automated match to d2zela_
    complexed with edo, so4, zn; mutant
  3. Domain d4yu9c_: 4yu9 C: [275754]
    automated match to d2zela_
    complexed with edo, so4, zn; mutant
22. Domains for 4ywy:
  1. Domain d4ywya_: 4ywy A: [275755]
    automated match to d2zema_
    complexed with cl, edo, pbd, so4, zn; mutant
  2. Domain d4ywyb_: 4ywy B: [275758]
    automated match to d2zema_
    complexed with cl, edo, pbd, so4, zn; mutant
  3. Domain d4ywyc_: 4ywy C: [275757]
    automated match to d2zema_
    complexed with cl, edo, pbd, so4, zn; mutant
Mouse (Mus musculus) [TaxId:10090] [189699] (2 PDB entries)
1. Domain for 3si1:
  - Domain d3si1a_: 3si1 A: [185408]
    automated match to d2afma1
    complexed with zn
2. Domain for 3si2:
  - Domain d3si2a_: 3si2 A: [185409]
    automated match to d2afma1
    complexed with act, pbd, so4, zn

More info for Protein Glutaminyl-peptide cyclotransferase, QPCT from c.56.5.8: Glutaminyl-peptide cyclotransferase-like

Timeline for Protein Glutaminyl-peptide cyclotransferase, QPCT from c.56.5.8: Glutaminyl-peptide cyclotransferase-like:

Protein Glutaminyl-peptide cyclotransferase, QPCT from c.56.5.8: Glutaminyl-peptide cyclotransferase-like first appeared in SCOP 1.73
Protein Glutaminyl-peptide cyclotransferase, QPCT from c.56.5.8: Glutaminyl-peptide cyclotransferase-like appears in SCOPe 2.05
Protein Glutaminyl-peptide cyclotransferase, QPCT from c.56.5.8: Glutaminyl-peptide cyclotransferase-like appears in SCOPe 2.07
Protein Glutaminyl-peptide cyclotransferase, QPCT from c.56.5.8: Glutaminyl-peptide cyclotransferase-like appears in the current release, SCOPe 2.08