Lineage for Family a.60.2.5: Hef domain-like

  1. Root: SCOP 1.73
  2. 631650Class a: All alpha proteins [46456] (258 folds)
  3. 642790Fold a.60: SAM domain-like [47768] (15 superfamilies)
    4-5 helices; bundle of two orthogonally packed alpha-hairpins; involved in the interactions with DNA and proteins
  4. 642894Superfamily a.60.2: RuvA domain 2-like [47781] (5 families) (S)
    duplication: contains two helix-hairpin-helix (HhH) motifs
  5. 642937Family a.60.2.5: Hef domain-like [140629] (3 proteins)
    helicase/nuclease domain; forms homo and heterodimers; probably includes the Excinuclease UvrC C-terminal domain (scop_fa 81795, that contains a single NMR structure of a monomeric truncated domain, 1kft)

Proteins:

  1. 642938ATP-dependent RNA helicase PF2015 [140632] (1 species)
  2. 642942DNA excision repair protein ERCC-1 [140630] (1 species)
  3. 642946DNA repair endonuclease XPF [140634] (2 species)
    1. 642947Species Aeropyrum pernix [TaxId:56636] [140635] (2 PDB entries)
    2. 642954Species Human (Homo sapiens) [TaxId:9606] [140636] (3 PDB entries)

More info for Family a.60.2.5: Hef domain-like

Timeline for Family a.60.2.5: Hef domain-like: