SCOPe 2.08: Domain d2uw9a_: 2uw9 A:

Lineage for d2uw9a_ (2uw9 A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Pkb kinase (Akt-2) [82791] (1 species)
   AGC group; RAC/Akt subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [82792] (16 PDB entries)

8. Domain d2uw9a_: 2uw9 A: [139988]
   automated match to d1o6la_
   complexed with gvp

Details for d2uw9a_

PDB Entry: 2uw9, 2.1 Å

PDB Description: structure of pkb-beta (akt2) complexed with 4-(4-chloro-phenyl)-4-(4-(1h-pyrazol-4-yl)-phenyl)-piperidine

PDB Compounds: (A:) rac-beta serine/threonine-protein kinase

SCOPe Domain Sequences for d2uw9a_:

Sequence, based on SEQRES records:

>d2uw9a_ d.144.1.7 (A:) Pkb kinase (Akt-2) {Human (Homo sapiens) [TaxId: 9606]}
kvtmndfdylkllgkgtfgkvilvrekatgryyamkilrkeviiakdevahtvtesrvlq
ntrhpfltalkyafqthdrlcfvmeyanggelffhlsrervfteerarfygaeivsaley
lhsrdvvyrdiklenlmldkdghikitdfglckegisdgatmktfcgtpeylapevledn
dygravdwwglgvvmyemmcgrlpfynqdherlfelilmeeirfprtlspeaksllagll
kkdpkqrlgggpsdakevmehrfflsinwqdvvqkkllppfkpqvtsevdtryfddefta
qsititppdrydslglleldqreeqemfedfdyiadw

Sequence, based on observed residues (ATOM records):

>d2uw9a_ d.144.1.7 (A:) Pkb kinase (Akt-2) {Human (Homo sapiens) [TaxId: 9606]}
kvtmndfdylkllgkgtfgkvilvrekatgryyamkilrkeviiakdevahtvtesrvlq
ntrhpfltalkyafqthdrlcfvmeyanggelffhlsrervfteerarfygaeivsaley
lhsrdvvyrdiklenlmldkdghikitdfglckegisdgatmktfcgtpeylapevledn
dygravdwwglgvvmyemmcgrlpfynqdherlfelilmeeirfprtlspeaksllagll
kkdpkqrlgggpsdakevmehrfflsinwqdvvqkkllppfkpqvtsevdtryfddefta
qsitqemfedfdyiadw

Timeline for d2uw9a_:

• d2uw9a_ first appeared in SCOP 1.73, called d2uw9a1
  
• d2uw9a_ appears in SCOPe 2.07