SCOPe 2.08: Domain d2o7na2: 2o7n A:129-307

Lineage for d2o7na2 (2o7n A:129-307)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.62: vWA-like [53299] (1 superfamily)
   core: 3 layers, a/b/a; mixed beta-sheet of 6 strands, order 321456; strand 3 is antiparallel to the rest

4. Superfamily c.62.1: vWA-like [53300] (6 families)

5. Family c.62.1.1: Integrin A (or I) domain [53301] (12 proteins)

6. Protein Integrin CD11a/CD18 (Leukocyte function associated antigen-1, LFA-1) [53302] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [53303] (26 PDB entries)
   Uniprot P20701 153-334

8. Domain d2o7na2: 2o7n A:129-307 [138929]
   Other proteins in same PDB: d2o7na3
   automated match to d1lfaa_
   complexed with 2o7

Details for d2o7na2

PDB Entry: 2o7n, 1.75 Å

PDB Description: cd11a (lfa1) i-domain complexed with 7a-[(4-cyanophenyl)methyl]-6-(3, 5-dichlorophenyl)-5-oxo-2,3,5,7a-tetrahydro-1h-pyrrolo[1,2-a]pyrrole- 7-carbonitrile

PDB Compounds: (A:) Integrin alpha-L

SCOPe Domain Sequences for d2o7na2:

Sequence; same for both SEQRES and ATOM records:

>d2o7na2 c.62.1.1 (A:129-307) Integrin CD11a/CD18 (Leukocyte function associated antigen-1, LFA-1) {Human (Homo sapiens) [TaxId: 9606]}
nvdlvflfdgsmslqpdefqkildfmkdvmkklsntsyqfaavqfstsyktefdfsdyvk
rkdpdallkhvkhmllltntfgainyvatevfreelgarpdatkvliiitdgeatdsgni
daakdiiryiigigkhfqtkesqetlhkfaskpasefvkildtfeklkdlftelqkkiy

Timeline for d2o7na2:

• d2o7na2 first appeared in SCOP 1.73, called d2o7na1
  
• d2o7na2 appears in SCOPe 2.07