SCOP 1.73: Domain d2o2ua1: 2o2u A:46-400

Lineage for d2o2ua1 (2o2u A:46-400)

1. Root: SCOP 1.73

2. Class d: Alpha and beta proteins (a+b) [53931] (334 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (7 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (61 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein c-jun N-terminal kinase (jnk3s) [56137] (1 species)
   CMGC group; ERK/MAPK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56138] (11 PDB entries)

8. Domain d2o2ua1: 2o2u A:46-400 [138892]
   automatically matched to d1jnk__
   complexed with 738

Details for d2o2ua1

PDB Entry: 2o2u, 2.45 Å

PDB Description: crystal structure of human jnk3 complexed with n-(3-cyano-4,5,6,7- tetrahydro-1-benzothien-2-yl)-2-fluorobenzamide

PDB Compounds: (A:) Mitogen-activated protein kinase 10

SCOP Domain Sequences for d2o2ua1:

Sequence, based on SEQRES records:

>d2o2ua1 d.144.1.7 (A:46-400) c-jun N-terminal kinase (jnk3s) {Human (Homo sapiens) [TaxId: 9606]}
nqfysvevgdstftvlkryqnlkpigsgaqgivcaaydavldrnvaikklsrpfqnqtha
krayrelvlmkcvnhkniisllnvftpqktleefqdvylvmelmdanlcqviqmeldher
msyllyqmlcgikhlhsagiihrdlkpsnivvksdctlkildfglartagtsfmmtpyvv
tryyrapevilgmgykenvdiwsvgcimgemvrhkilfpgrdyidqwnkvieqlgtpcpe
fmkklqptvrnyvenrpkyagltfpklfpdslfpadsehnklkasqardllskmlvidpa
krisvddalqhpyinvwydpaeveapppqiydkqlderehtieewkeliykevmn

Sequence, based on observed residues (ATOM records):

>d2o2ua1 d.144.1.7 (A:46-400) c-jun N-terminal kinase (jnk3s) {Human (Homo sapiens) [TaxId: 9606]}
nqfysvevgdstftvlkryqnlkpigsggivcaaydavldrnvaikklsrpfqnqthakr
ayrelvlmkcvnhkniisllnvftpqktleefqdvylvmelmdanlcqviqmeldherms
yllyqmlcgikhlhsagiihrdlkpsnivvksdctlkildfglavtryyrapevilgmgy
kenvdiwsvgcimgemvrhkilfpgrdyidqwnkvieqlgtpcpefmkklqptvrnyven
rpkyagltfpklfpdslfpadsehnklkasqardllskmlvidpakrisvddalqhpyin
vwyhtieewkeliykevmn

Timeline for d2o2ua1:

• d2o2ua1 is new in SCOP 1.73
  
• d2o2ua1 appears in SCOP 1.75
  
• d2o2ua1 appears in the current release, SCOPe 2.08, called d2o2ua_