SCOPe 2.03: Domain d2nptd_: 2npt D:

Lineage for d2nptd_ (2npt D:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.15: beta-Grasp (ubiquitin-like) [54235] (14 superfamilies)
   core: beta(2)-alpha-beta(2); mixed beta-sheet 2143

4. Superfamily d.15.2: CAD & PB1 domains [54277] (2 families)
   contain extra helix; similar heterodimerization modes; possibly related to the ubiquitin-like superfamily

5. Family d.15.2.2: PB1 domain [64225] (11 proteins)
   Pfam PF00564
   forms heterodimers, although not all PB1 domain pairs associate.

6. Protein Mitogen-activated protein kinase kinase kinase 2, MEKK 2 [142976] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [142977] (2 PDB entries)
   Uniprot Q9Y2U5 42-123! Uniprot Q9Y2U5 43-132

8. Domain d2nptd_: 2npt D: [138451]
   Other proteins in same PDB: d2npta1, d2nptc_
   automated match to d2nptb1

Details for d2nptd_

PDB Entry: 2npt, 1.75 Å

PDB Description: Crystal Structure of the complex of human mitogen activated protein kinase kinase 5 phox domain (MAP2K5-phox) with human mitogen activated protein kinase kinase kinase 2 phox domain (MAP3K2-phox)

PDB Compounds: (D:) Mitogen-activated protein kinase kinase kinase 2

SCOPe Domain Sequences for d2nptd_:

Sequence; same for both SEQRES and ATOM records:

>d2nptd_ d.15.2.2 (D:) Mitogen-activated protein kinase kinase kinase 2, MEKK 2 {Human (Homo sapiens) [TaxId: 9606]}
ssspkkqndvrvkfehrgekrilqfprpvkledlrskakiafgqsmdlhytnnelviplt
tqddldkavelldrsihmkslkillvin

Timeline for d2nptd_:

• d2nptd_ first appeared in SCOP 1.73, called d2nptd1
  
• d2nptd_ appears in SCOPe 2.02
  
• d2nptd_ appears in SCOPe 2.04
  
• d2nptd_ appears in the current release, SCOPe 2.08