SCOPe 2.05: Domain d2np0a3: 2np0 A:1-533

Lineage for d2np0a3 (2np0 A:1-533)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.92: Zincin-like [55485] (2 superfamilies)
   contains mixed beta sheet with connection over free side of the sheet

4. Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain [55486] (18 families)

5. Family d.92.1.7: Clostridium neurotoxins, catalytic domain [55512] (2 proteins)

6. Protein Botulinum neurotoxin [55513] (4 species)

7. Species Clostridium botulinum, serotype B [TaxId:1491] [55515] (16 PDB entries)

8. Domain d2np0a3: 2np0 A:1-533 [138418]
   Other proteins in same PDB: d2np0a1, d2np0a2, d2np0a4
   automated match to d1epwa3
   complexed with ca, cl, zn

Details for d2np0a3

PDB Entry: 2np0, 2.62 Å

PDB Description: Crystal structure of the Botulinum neurotoxin type B complexed with synaptotagamin-II ectodomain

PDB Compounds: (A:) botulinum neurotoxin type b

SCOPe Domain Sequences for d2np0a3:

Sequence, based on SEQRES records:

>d2np0a3 d.92.1.7 (A:1-533) Botulinum neurotoxin {Clostridium botulinum, serotype B [TaxId: 1491]}
pvtinnfnyndpidnnniimmeppfargtgryykafkitdriwiiperytfgykpedfnk
ssgifnrdvceyydpdylntndkkniflqtmiklfnrikskplgekllemiingipylgd
rrvpleefntniasvtvnklisnpgeverkkgifanliifgpgpvlnenetidigiqnhf
asregfggimqmkfcpeyvsvfnnvqenkgasifnrrgyfsdpalilmhelihvlhglyg
ikvddlpivpnekkffmqstdaiqaeelytfggqdpsiitpstdksiydkvlqnfrgivd
rlnkvlvcisdpnininiyknkfkdkykfvedsegkysidvesfdklykslmfgftetni
aenykiktrasyfsdslppvkiknlldneiytieegfnisdkdmekeyrgqnkainkqay
eeiskehlavykiqmcksvkapgicidvdnedlffiadknsfsddlsknerieyntqsny
iendfpinelildtdliskielpsentesltdfnvdvpvyekqpaikkiftde

Sequence, based on observed residues (ATOM records):

>d2np0a3 d.92.1.7 (A:1-533) Botulinum neurotoxin {Clostridium botulinum, serotype B [TaxId: 1491]}
pvtinnfnyndpidnnniimmeppfargtgryykafkitdriwiiperytfgykpedfnk
ssgifnrdvceyydpdylntndkkniflqtmiklfnrikskplgekllemiingipylgd
rrvpleefntniasvtvnklisnpgeverkkgifanliifgpgpvlnenetidigiqnhf
asregfggimqmkfcpeyvsvfnnvqenkgasifnrrgyfsdpalilmhelihvlhglyg
ikvddlpivpnekkffmqstdaiqaeelytfggqdpsiitpstdksiydkvlqnfrgivd
rlnkvlvcisdpnininiyknkfkdkykfvedsegkysidvesfdklykslmfgftetni
aenykiktrasyfsdslppvkiknlldneiytieegfnisdkdmekeyrgqnkainkqay
eeiskehlavykiqmcksvkpgicidvdnedlffiadknsfsddlsknerieyntqsnyi
endfpinelildtdliskielpsentesltdfnvdvpvyekqpaikkiftde

Timeline for d2np0a3:

• d2np0a3 first appeared in SCOP 1.73
  
• d2np0a3 appears in SCOPe 2.04
  
• d2np0a3 appears in SCOPe 2.06
  
• d2np0a3 appears in the current release, SCOPe 2.08