SCOPe 2.02: Domain d2j6eb2: 2j6e B:340-445

Lineage for d2j6eb2 (2j6e B:340-445)

1. Root: SCOPe 2.02

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (28 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (24 proteins)

6. Protein Immunoglobulin heavy chain gamma constant domain 3, CH3-gamma [88589] (5 species)

7. Species Human (Homo sapiens) [TaxId:9606] [88590] (28 PDB entries)
   Uniprot P01857 #118-327 ! Uniprot P01857 118-327 # GC1_HUMAN Ig gamma-1 chain C region

8. Domain d2j6eb2: 2j6e B:340-445 [138083]
   Other proteins in same PDB: d2j6ea1, d2j6eb1, d2j6eh1, d2j6eh2, d2j6ei1, d2j6ei2, d2j6el1, d2j6el2, d2j6em1, d2j6em2
   automatically matched to d1hzhh4
   complexed with act, cac, cd, mpd, zn

Details for d2j6eb2

PDB Entry: 2j6e, 3 Å

PDB Description: crystal structure of an autoimmune complex between a human igm rheumatoid factor and igg1 fc reveals a novel fc epitope and evidence for affinity maturation

PDB Compounds: (B:) Ig gamma-1 chain C region

SCOPe Domain Sequences for d2j6eb2:

Sequence; same for both SEQRES and ATOM records:

>d2j6eb2 b.1.1.2 (B:340-445) Immunoglobulin heavy chain gamma constant domain 3, CH3-gamma {Human (Homo sapiens) [TaxId: 9606]}
kgqprepqvytlppsrdeltknqvsltclvkgfypsdiavewesngqpennykttppvld
sdgsfflyskltvdksrwqqgnvfscsvmhealhnhytqkslslsp

Timeline for d2j6eb2:

• d2j6eb2 first appeared in SCOP 1.73
  
• d2j6eb2 appears in SCOPe 2.01
  
• d2j6eb2 appears in SCOPe 2.03
  
• d2j6eb2 appears in the current release, SCOPe 2.08