SCOPe 2.03: Domain d2j50a1: 2j50 A:128-388

Lineage for d2j50a1 (2j50 A:128-388)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Aurora-related kinase 1 (aurora-2) [90038] (1 species)
   OPK group; AIRK subfamily; serine/threonine kinase
7. Species Human (Homo sapiens) [TaxId:9606] [90039] (17 PDB entries)

8. Domain d2j50a1: 2j50 A:128-388 [138011]
   automatically matched to d1ol5a_
   complexed with 627, so4

Details for d2j50a1

PDB Entry: 2j50, 3 Å

PDB Description: structure of aurora-2 in complex with pha-739358

PDB Compounds: (A:) serine/threonine-protein kinase 6

SCOPe Domain Sequences for d2j50a1:

Sequence, based on SEQRES records:

>d2j50a1 d.144.1.7 (A:128-388) Aurora-related kinase 1 (aurora-2) {Human (Homo sapiens) [TaxId: 9606]}
waledfeigrplgkgkfgnvylarekqskfilalkvlfkaqlekagvehqlrreveiqsh
lrhpnilrlygyfhdatrvylileyaplgtvyrelqklskfdeqrtatyitelanalsyc
hskrvihrdikpenlllgsagelkiadfgwsvhapssrrttlcgtldylppemiegrmhd
ekvdlwslgvlcyeflvgkppfeantyqetykrisrveftfpdfvtegardlisrllkhn
psqrpmlrevlehpwitanss

Sequence, based on observed residues (ATOM records):

>d2j50a1 d.144.1.7 (A:128-388) Aurora-related kinase 1 (aurora-2) {Human (Homo sapiens) [TaxId: 9606]}
waledfeigrplgkgkfgnvylarekqskfilalkvlfkaqlekagvehqlrreveiqsh
lrhpnilrlygyfhdatrvylileyaplgtvyrelqklskfdeqrtatyitelanalsyc
hskrvihrdikpenlllgsagelkiadfgwsvtlcgtldylppemiedekvdlwslgvlc
yeflvgkppfeantyqetykrisrveftfpdfvtegardlisrllkhnpsqrpmlrevle
hpwitanss

Timeline for d2j50a1:

• d2j50a1 first appeared in SCOP 1.73
  
• d2j50a1 appears in SCOPe 2.02
  
• d2j50a1 is called d2j50a_ in SCOPe 2.04
  
• d2j50a1 appears in the current release, SCOPe 2.08, called d2j50a_