SCOPe 2.04: Domain d2iw9b1: 2iw9 B:176-309

Lineage for d2iw9b1 (2iw9 B:176-309)

1. Root: SCOPe 2.04

2. Class a: All alpha proteins [46456] (285 folds)

3. Fold a.74: Cyclin-like [47953] (1 superfamily)
   core: 5 helices; one helix is surrounded by the others

4. Superfamily a.74.1: Cyclin-like [47954] (4 families)
   duplication: consists of two domains of this fold

5. Family a.74.1.1: Cyclin [47955] (9 proteins)

6. Protein Cyclin A [47956] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [47957] (74 PDB entries)
   Uniprot P20248 175-432

8. Domain d2iw9b1: 2iw9 B:176-309 [137748]
   Other proteins in same PDB: d2iw9a_, d2iw9c_
   automated match to d1oi9b1
   complexed with 4sp, mg, sgm

Details for d2iw9b1

PDB Entry: 2iw9, 2 Å

PDB Description: structure of human thr160-phospho cdk2-cyclin a complexed with a bisanilinopyrimidine inhibitor

PDB Compounds: (B:) Cyclin-A2

SCOPe Domain Sequences for d2iw9b1:

Sequence, based on SEQRES records:

>d2iw9b1 a.74.1.1 (B:176-309) Cyclin A {Human (Homo sapiens) [TaxId: 9606]}
pdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqnetlhla
vnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkqvlrme
hlvlkvltfdlaap

Sequence, based on observed residues (ATOM records):

>d2iw9b1 a.74.1.1 (B:176-309) Cyclin A {Human (Homo sapiens) [TaxId: 9606]}
pdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqnetlhla
vnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyittytkkqvlrmehl
vlkvltfdlaap

Timeline for d2iw9b1:

• d2iw9b1 first appeared in SCOP 1.73
  
• d2iw9b1 appears in SCOPe 2.03
  
• d2iw9b1 appears in SCOPe 2.05
  
• d2iw9b1 appears in the current release, SCOPe 2.08