SCOPe 2.01: Domain d2iw8b1: 2iw8 B:181-308

Lineage for d2iw8b1 (2iw8 B:181-308)

1. Root: SCOPe 2.01

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.74: Cyclin-like [47953] (1 superfamily)
   core: 5 helices; one helix is surrounded by the others

4. Superfamily a.74.1: Cyclin-like [47954] (3 families)
   duplication: consists of two domains of this fold

5. Family a.74.1.1: Cyclin [47955] (8 proteins)

6. Protein Cyclin A [47956] (2 species)

7. Species Cow (Bos taurus) [TaxId:9913] [47958] (25 PDB entries)

8. Domain d2iw8b1: 2iw8 B:181-308 [137744]
   Other proteins in same PDB: d2iw8a1, d2iw8c_
   automatically matched to d1vin_1
   complexed with 4sp, sgm; mutant

Details for d2iw8b1

PDB Entry: 2iw8, 2.3 Å

PDB Description: structure of human thr160-phospho cdk2-cyclin a f82h-l83v-h84d mutant with an o6-cyclohexylmethylguanine inhibitor

PDB Compounds: (B:) Cyclin-A2

SCOPe Domain Sequences for d2iw8b1:

Sequence, based on SEQRES records:

>d2iw8b1 a.74.1.1 (B:181-308) Cyclin A {Cow (Bos taurus) [TaxId: 9913]}
dihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqnetlhlavnyid
rflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkqvlrmehlvlk
vltfdlaa

Sequence, based on observed residues (ATOM records):

>d2iw8b1 a.74.1.1 (B:181-308) Cyclin A {Cow (Bos taurus) [TaxId: 9913]}
dihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqnetlhlavnyid
rflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyittytkkqvlrmehlvlkvl
tfdlaa

Timeline for d2iw8b1:

• d2iw8b1 first appeared in SCOP 1.73
  
• d2iw8b1 appears in SCOP 1.75
  
• d2iw8b1 appears in SCOPe 2.02
  
• d2iw8b1 appears in the current release, SCOPe 2.08