SCOPe 2.05: Domain d2ii0a_: 2ii0 A:

Lineage for d2ii0a_ (2ii0 A:)

1. Root: SCOPe 2.05

2. Class a: All alpha proteins [46456] (286 folds)

3. Fold a.117: Ras GEF [48365] (1 superfamily)
   multihelical

4. Superfamily a.117.1: Ras GEF [48366] (1 family)

5. Family a.117.1.1: Ras GEF [48367] (2 proteins)

6. Protein Son of sevenless protein homolog 1 (sos-1) [48368] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48369] (11 PDB entries)
   Uniprot Q07889 189-1046

8. Domain d2ii0a_: 2ii0 A: [137425]
   automated match to d1nvus_

Details for d2ii0a_

PDB Entry: 2ii0, 2.02 Å

PDB Description: Crystal Structure of catalytic domain of Son of sevenless (Rem-Cdc25) in the absence of Ras

PDB Compounds: (A:) Son of sevenless homolog 1

SCOPe Domain Sequences for d2ii0a_:

Sequence, based on SEQRES records:

>d2ii0a_ a.117.1.1 (A:) Son of sevenless protein homolog 1 (sos-1) {Human (Homo sapiens) [TaxId: 9606]}
qmrlpsadvyrfaepdseeniifeenmqpkagipiikagtviklierltyhmyadpnfvr
tflttyrsfckpqellsliierfeipepepteadriaiengdqplsaelkrfrkeyiqpv
qlrvlnvcrhwvehhfydferdayllqrmeefigtvrgkamkkwvesitkiiqrkkiard
ngpghnitfqsspptvewhisrpghietfdlltlhpieiarqltllesdlyravqpselv
gsvwtkedkeinspnllkmirhttnltlwfekcivetenleervavvsriieilqvfqel
nnfngvlevvsamnsspvyrldhtfeqipsrqkkileeahelsedhykkylaklrsinpp
cvpffgiyltnilkteegnpevlkrhgkelinfskrrkvaeitgeiqqyqnqpyclrves
dikrffenlnpmgnsmekeftdylfnksleieprnpkplprfpkkysyplkspgvrpsnp

Sequence, based on observed residues (ATOM records):

>d2ii0a_ a.117.1.1 (A:) Son of sevenless protein homolog 1 (sos-1) {Human (Homo sapiens) [TaxId: 9606]}
qmrlpsadvyrfaepdseeniifegipiikagtviklierltyhmyadpnfvrtflttyr
sfckpqellsliierfeipepepteadriaiengdqplsaelkrfrkeyiqpvqlrvlnv
crhwvehhfydferdayllqrmeefigtvrgkamkkwvesitkiiqrkkiafqsspptve
whisrpghietfdlltlhpieiarqltllesdlyravqpselvgsvwtkedkeinspnll
kmirhttnltlwfekcivetenleervavvsriieilqvfqelnnfngvlevvsamnssp
vyrldhtfeqipsrqkkileeahelsedhykkylaklrsinppcvpffgiyltnilktee
gnpevlkrhgkelinfskrrkvaeitgeiqqyqnqpyclrvesdikrffenlnpmgnsme
keftdylfnksleieprnpkplprfpkkysyplkspgvrpsnp

Timeline for d2ii0a_:

• d2ii0a_ first appeared in SCOP 1.73, called d2ii0a1
  
• d2ii0a_ appears in SCOPe 2.04
  
• d2ii0a_ appears in SCOPe 2.06
  
• d2ii0a_ appears in the current release, SCOPe 2.08