SCOP 1.73: Domain d2ianl2: 2ian L:3-92

Lineage for d2ianl2 (2ian L:3-92)

1. Root: SCOP 1.73

2. Class d: Alpha and beta proteins (a+b) [53931] (334 folds)

3. Fold d.19: MHC antigen-recognition domain [54451] (1 superfamily)
   dimeric

4. Superfamily d.19.1: MHC antigen-recognition domain [54452] (1 family)

5. Family d.19.1.1: MHC antigen-recognition domain [54453] (12 proteins)

6. Protein Class II MHC beta chain, N-terminal domain [88819] (15 species)

7. Species Human (Homo sapiens), HLA-DR4 [TaxId:9606] [88824] (12 PDB entries)

8. Domain d2ianl2: 2ian L:3-92 [137173]
   Other proteins in same PDB: d2iana1, d2iana2, d2ianb1, d2ianf1, d2ianf2, d2iang1, d2iank1, d2iank2, d2ianl1, d2ianp1, d2ianp2, d2ianq1
   automatically matched to d1d5xb2
   mutant

Details for d2ianl2

PDB Entry: 2ian, 2.8 Å

PDB Description: Structural basis for recognition of mutant self by a tumor-specific, MHC class II-restricted TCR

PDB Compounds: (L:) HLA class II histocompatibility antigen, DRB1-1 beta chain

SCOP Domain Sequences for d2ianl2:

Sequence; same for both SEQRES and ATOM records:

>d2ianl2 d.19.1.1 (L:3-92) Class II MHC beta chain, N-terminal domain {Human (Homo sapiens), HLA-DR4 [TaxId: 9606]}
trprflwqlkfechffngtervrllerciynqeesvrfdsdvgeyravtelgrpdaeywn
sqkdlleqrraavdtycrhnygvgesftvq

Timeline for d2ianl2:

• d2ianl2 is new in SCOP 1.73
  
• d2ianl2 appears in SCOP 1.75
  
• d2ianl2 appears in the current release, SCOPe 2.08