SCOPe 2.03: Domain d2i5yr2: 2i5y R:114-214

Lineage for d2i5yr2 (2i5y R:114-214)

1. Root: SCOPe 2.03

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (28 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (24 proteins)

6. Protein Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma [88574] (6 species)

7. Species Human (Homo sapiens) [TaxId:9606] [88575] (177 PDB entries)
   including humanized antibodies (chimeric proteins with human constant domains)
   Uniprot Q6N089 20-243 # 95% sequence identity; natural chimera: antibody heavy chain (Fab HYB3) ! SQ NA # humanized antibody ! Uniprot P01857 # IGHG1_HUMAN Ig gamma-1 chain C region ! SQ NA # engineered antibody

8. Domain d2i5yr2: 2i5y R:114-214 [137080]
   Other proteins in same PDB: d2i5yg_, d2i5yh1, d2i5yl1, d2i5yl2, d2i5ym1, d2i5yp_, d2i5yq1, d2i5yq2, d2i5yr1, d2i5ys1
   automatically matched to d1ngzb2
   complexed with nag, ndg

Details for d2i5yr2

PDB Entry: 2i5y, 2.2 Å

PDB Description: crystal structure of cd4m47, a scorpion-toxin mimic of cd4, in complex with hiv-1 yu2 gp120 envelope glycoprotein and anti-hiv-1 antibody 17b

PDB Compounds: (R:) Antibody 17B Heavy chain

SCOPe Domain Sequences for d2i5yr2:

Sequence, based on SEQRES records:

>d2i5yr2 b.1.1.2 (R:114-214) Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma {Human (Homo sapiens) [TaxId: 9606]}
astkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqss
glyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepk

Sequence, based on observed residues (ATOM records):

>d2i5yr2 b.1.1.2 (R:114-214) Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma {Human (Homo sapiens) [TaxId: 9606]}
astkgpsvfplapsgtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglysls
svvtvpssslgtqtyicnvnhkpsntkvdkkvepk

Timeline for d2i5yr2:

• d2i5yr2 first appeared in SCOP 1.73
  
• d2i5yr2 appears in SCOPe 2.02
  
• d2i5yr2 appears in SCOPe 2.04
  
• d2i5yr2 appears in the current release, SCOPe 2.08