SCOP 1.75: Domain d2hlff1: 2hlf F:1-105

Lineage for d2hlff1 (2hlf F:1-105)

1. Root: SCOP 1.75

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (28 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (4 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (32 proteins)

6. Protein Immunoglobulin light chain kappa variable domain, VL-kappa [88519] (16 species)
   VL-kappa domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VL-kappa domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Mouse (Mus musculus), cluster 3.2 [TaxId:10090] [88528] (44 PDB entries)
   Uniprot P04940 # KV6F_MOUSE IG KAPPA CHAIN V-VI REGION NQ2-17.4.1

8. Domain d2hlff1: 2hlf F:1-105 [136568]
   Other proteins in same PDB: d2hlfa1, d2hlfb1, d2hlfd2, d2hlff2
   automatically matched to d1dqdl1
   complexed with br; mutant

Details for d2hlff1

PDB Entry: 2hlf, 3.3 Å

PDB Description: structure of the escherichis coli clc chloride channel y445e mutant and fab complex

PDB Compounds: (F:) Fab fragment, light chain

SCOP Domain Sequences for d2hlff1:

Sequence; same for both SEQRES and ATOM records:

>d2hlff1 b.1.1.1 (F:1-105) Immunoglobulin light chain kappa variable domain, VL-kappa {Mouse (Mus musculus), cluster 3.2 [TaxId: 10090]}
divltqspaimsaapgdkvtmtcsasssvsyihwyqqksgtspkrwiydtskltsgvpvr
fsgsgsgtsysltintmeaedaatyycqqwsshpqtfgggtklei

Timeline for d2hlff1:

• d2hlff1 first appeared in SCOP 1.73
  
• d2hlff1 appears in SCOPe 2.01
  
• d2hlff1 appears in the current release, SCOPe 2.08