SCOPe 2.07: Domain d2h9gh1: 2h9g H:1-113

Lineage for d2h9gh1 (2h9g H:1-113)

1. Root: SCOPe 2.07

2. Class b: All beta proteins [48724] (178 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (33 proteins)

6. Protein Immunoglobulin heavy chain variable domain, VH [88543] (22 species)
   VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Engineered (including hybrid species) [88562] (71 PDB entries)
   SQ NA # humanized antidoby; bactericidal Fab-h6831 ! SQ NA # humanized antibody ! SQ NA # Humanized antibody ! SQ NA # engineered antibody

8. Domain d2h9gh1: 2h9g H:1-113 [136259]
   Other proteins in same PDB: d2h9ga1, d2h9ga2, d2h9gb2, d2h9gh2, d2h9gl1, d2h9gl2, d2h9gr1, d2h9gr2, d2h9gr3, d2h9gs1
   automatically matched to d1fvcb_

Details for d2h9gh1

PDB Entry: 2h9g, 2.32 Å

PDB Description: Crystal structure of phage derived Fab BdF1 with human Death Receptor 5 (DR5)

PDB Compounds: (H:) Fab BdF1, heavy chain

SCOPe Domain Sequences for d2h9gh1:

Sequence; same for both SEQRES and ATOM records:

>d2h9gh1 b.1.1.1 (H:1-113) Immunoglobulin heavy chain variable domain, VH {Engineered (including hybrid species)}
evqlvesggglvqpggslrlscaasgfsigksgihwvrqapgkglewvaviyphdgntay
adsvkgrftisadtskntaylqmnslraedtavyycarrlalvrmwmdywgqgtlvtvss

Timeline for d2h9gh1:

• d2h9gh1 first appeared in SCOP 1.73
  
• d2h9gh1 appears in SCOPe 2.06
  
• d2h9gh1 appears in the current release, SCOPe 2.08