SCOPe 2.04: Domain d2h42b_: 2h42 B:

Lineage for d2h42b_ (2h42 B:)

1. Root: SCOPe 2.04

2. Class a: All alpha proteins [46456] (285 folds)

3. Fold a.211: HD-domain/PDEase-like [109603] (1 superfamily)
   multihelical; consists of two different alpha-helical bundles

4. Superfamily a.211.1: HD-domain/PDEase-like [109604] (6 families)

5. Family a.211.1.2: PDEase [48548] (7 proteins)
   Pfam PF00233; multihelical; can be divided into three subdomains

6. Protein cGMP-specific 3',5'-cyclic phosphodiesterase pde5a1-Ibmx [101439] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [101440] (18 PDB entries)
   Uniprot O76074 534-860

8. Domain d2h42b_: 2h42 B: [136065]
   automated match to d1rkpa_
   complexed with mg, via, zn

Details for d2h42b_

PDB Entry: 2h42, 2.3 Å

PDB Description: Crystal structure of PDE5 in complex with sildenafil

PDB Compounds: (B:) cGMP-specific 3',5'-cyclic phosphodiesterase

SCOPe Domain Sequences for d2h42b_:

Sequence, based on SEQRES records:

>d2h42b_ a.211.1.2 (B:) cGMP-specific 3',5'-cyclic phosphodiesterase pde5a1-Ibmx {Human (Homo sapiens) [TaxId: 9606]}
eetrelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhev
lcrwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalshd
ldhrgvnnsyiqrsehplaqlychsimehhhfdqclmilnspgnqilsglsieeykttlk
iikqailatdlalyikrrgeffelirknqfnledphqkelflamlmtacdlsaitkpwpi
qqriaelvateffdqgdrerkelnieptdlmnrekknkipsmqvgfidaiclqlyealth
vsedcfplldgcrknrqkwqalaeqq

Sequence, based on observed residues (ATOM records):

>d2h42b_ a.211.1.2 (B:) cGMP-specific 3',5'-cyclic phosphodiesterase pde5a1-Ibmx {Human (Homo sapiens) [TaxId: 9606]}
eetrelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhev
lcrwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalshd
ldhrgvnnsyiqrchsimehhhfdqclmilnspgnqilsglsieeykttlkiikqailat
dlalyikrrgeffelirknqfnledphqkelflamlmtacdlsaitkpwpiqqriaelva
teffdqgdrerkelnieptdlmnrekknkipsmqvgfidaiclqlyealthvsedcfpll
dgcrknrqkwqalaeqq

Timeline for d2h42b_:

• d2h42b_ first appeared in SCOP 1.73, called d2h42b1
  
• d2h42b_ appears in SCOPe 2.03
  
• d2h42b_ appears in SCOPe 2.05
  
• d2h42b_ appears in the current release, SCOPe 2.08