Lineage for d2h42b1 (2h42 B:535-860)

  1. Root: SCOP 1.75
  2. 758332Class a: All alpha proteins [46456] (284 folds)
  3. 780219Fold a.211: HD-domain/PDEase-like [109603] (1 superfamily)
    multihelical; consists of two different alpha-helical bundles
  4. 780220Superfamily a.211.1: HD-domain/PDEase-like [109604] (5 families) (S)
  5. 780284Family a.211.1.2: PDEase [48548] (6 proteins)
    Pfam PF00233; multihelical; can be divided into three subdomains
  6. 780402Protein cGMP-specific 3',5'-cyclic phosphodiesterase pde5a1-Ibmx [101439] (1 species)
  7. 780403Species Human (Homo sapiens) [TaxId:9606] [101440] (15 PDB entries)
    Uniprot O76074 534-860
  8. 780418Domain d2h42b1: 2h42 B:535-860 [136065]
    automatically matched to d1t9ra_
    complexed with mg, via, zn

Details for d2h42b1

PDB Entry: 2h42 (more details), 2.3 Å

PDB Description: Crystal structure of PDE5 in complex with sildenafil
PDB Compounds: (B:) cGMP-specific 3',5'-cyclic phosphodiesterase

SCOP Domain Sequences for d2h42b1:

Sequence, based on SEQRES records: (download)

>d2h42b1 a.211.1.2 (B:535-860) cGMP-specific 3',5'-cyclic phosphodiesterase pde5a1-Ibmx {Human (Homo sapiens) [TaxId: 9606]}
eetrelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhev
lcrwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalshd
ldhrgvnnsyiqrsehplaqlychsimehhhfdqclmilnspgnqilsglsieeykttlk
iikqailatdlalyikrrgeffelirknqfnledphqkelflamlmtacdlsaitkpwpi
qqriaelvateffdqgdrerkelnieptdlmnrekknkipsmqvgfidaiclqlyealth
vsedcfplldgcrknrqkwqalaeqq

Sequence, based on observed residues (ATOM records): (download)

>d2h42b1 a.211.1.2 (B:535-860) cGMP-specific 3',5'-cyclic phosphodiesterase pde5a1-Ibmx {Human (Homo sapiens) [TaxId: 9606]}
eetrelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhev
lcrwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalshd
ldhrgvnnsyiqrchsimehhhfdqclmilnspgnqilsglsieeykttlkiikqailat
dlalyikrrgeffelirknqfnledphqkelflamlmtacdlsaitkpwpiqqriaelva
teffdqgdrerkelnieptdlmnrekknkipsmqvgfidaiclqlyealthvsedcfpll
dgcrknrqkwqalaeqq

SCOP Domain Coordinates for d2h42b1:

Click to download the PDB-style file with coordinates for d2h42b1.
(The format of our PDB-style files is described here.)

Timeline for d2h42b1: