SCOPe 2.06: Domain d2gk1h1: 2gk1 H:200-552

Lineage for d2gk1h1 (2gk1 H:200-552)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.8: (Trans)glycosidases [51445] (15 families)

5. Family c.1.8.6: beta-N-acetylhexosaminidase catalytic domain [51550] (6 proteins)
   Glycosyl hydrolase family 20, GH20
   automatically mapped to Pfam PF00728

6. Protein beta-hexosaminidase B [89486] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [89487] (6 PDB entries)

8. Domain d2gk1h1: 2gk1 H:200-552 [135325]
   Other proteins in same PDB: d2gk1a1, d2gk1a2, d2gk1b2, d2gk1c1, d2gk1c2, d2gk1d2, d2gk1e1, d2gk1e2, d2gk1f2, d2gk1g1, d2gk1g2, d2gk1h2
   automatically matched to d1o7aa1
   complexed with ngt

Details for d2gk1h1

PDB Entry: 2gk1, 3.25 Å

PDB Description: x-ray crystal structure of ngt-bound hexa

PDB Compounds: (H:) beta-hexosaminidase beta chain

SCOPe Domain Sequences for d2gk1h1:

Sequence, based on SEQRES records:

>d2gk1h1 c.1.8.6 (H:200-552) beta-hexosaminidase B {Human (Homo sapiens) [TaxId: 9606]}
fshrgilidtsrhylpvkiilktldamafnkfnvlhwhivddqsfpyqsitfpelsnkgs
yslshvytpndvrmvieyarlrgirvlpefdtpghtlswgkgqkdlltpcysrqnkldsf
gpinptlnttysflttffkeisevfpdqfihlggdevefkcwesnpkiqdfmrqkgfgtd
fkklesfyiqkvldiiatinkgsivwqevfddkaklapgtivevwkdsaypeelsrvtas
gfpvilsapwyldlisygqdwrkyykvepldfggtqkqkqlfiggeaclwgeyvdatnlt
prlwprasavgerlwsskdvrdmddaydrltrhrcrmvergiaaqplyagycn

Sequence, based on observed residues (ATOM records):

>d2gk1h1 c.1.8.6 (H:200-552) beta-hexosaminidase B {Human (Homo sapiens) [TaxId: 9606]}
fshrgilidtsrhylpvkiilktldamafnkfnvlhwhivddqsfpyqsitfpelsnkgs
yslshvytpndvrmvieyarlrgirvlpefdtpghtlswgkgqkdlltpcysdsfgpinp
tlnttysflttffkeisevfpdqfihlggdevefkcwesnpkiqdfmrqkgfgtdfkkle
sfyiqkvldiiatinkgsivwqevfddkaklapgtivevwkdsaypeelsrvtasgfpvi
lsapwyldlisygqdwrkyykvepldfggtqkqkqlfiggeaclwgeyvdatnltprlwp
rasavgerlwsskdvrdmddaydrltrhrcrmvergiaaqplyagycn

Timeline for d2gk1h1:

• d2gk1h1 first appeared in SCOP 1.73
  
• d2gk1h1 appears in SCOPe 2.05
  
• d2gk1h1 does not appear in SCOPe 2.07