SCOP 1.75: Domain d2fzza1: 2fzz A:16-244

Lineage for d2fzza1 (2fzz A:16-244)

1. Root: SCOP 1.75

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (4 families)

5. Family b.47.1.2: Eukaryotic proteases [50514] (47 proteins)

6. Protein Coagulation factor Xa, protease domain [50574] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50575] (75 PDB entries)
   Uniprot P00742 235-467

8. Domain d2fzza1: 2fzz A:16-244 [134486]
   Other proteins in same PDB: d2fzzl1
   automatically matched to d1c5md_
   complexed with 5qc

Details for d2fzza1

PDB Entry: 2fzz, 2.2 Å

PDB Description: Factor Xa in complex with the inhibitor 1-(3-amino-1,2-benzisoxazol-5-yl)-6-(2'-(((3r)-3-hydroxy-1-pyrrolidinyl)methyl)-4-biphenylyl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7h-pyrazolo[3,4-c]pyridin-7-one

PDB Compounds: (A:) coagulation factor x

SCOP Domain Sequences for d2fzza1:

Sequence; same for both SEQRES and ATOM records:

>d2fzza1 b.47.1.2 (A:16-244) Coagulation factor Xa, protease domain {Human (Homo sapiens) [TaxId: 9606]}
ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
tqktgivsgfgrthekgrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmkt

Timeline for d2fzza1:

• d2fzza1 first appeared in SCOP 1.73
  
• d2fzza1 is called d2fzza_ in SCOPe 2.01
  
• d2fzza1 appears in the current release, SCOPe 2.08, called d2fzza_