SCOPe 2.05: Domain d2fx9m2: 2fx9 M:108-213

Lineage for d2fx9m2 (2fx9 M:108-213)

1. Root: SCOPe 2.05

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (31 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (24 proteins)

6. Protein Immunoglobulin light chain kappa constant domain, CL-kappa [88566] (4 species)

7. Species Human (Homo sapiens) [TaxId:9606] [88569] (144 PDB entries)
   including humanized antibodies (chimeric proteins with human constant domains)
   SQ NA # humanized antibody ! Uniprot P01834 # KAC_HUMAN Ig kappa chain C region ! SQ P01834 # KAC_HUMAN Ig kappa chain C region. ! SQ NA # engineered antibody

8. Domain d2fx9m2: 2fx9 M:108-213 [134303]
   Other proteins in same PDB: d2fx9h1, d2fx9h2, d2fx9i1, d2fx9i2, d2fx9l1, d2fx9m1
   automatically matched to d1rhha2

Details for d2fx9m2

PDB Entry: 2fx9, 2.1 Å

PDB Description: Crystal structure of hiv-1 neutralizing human fab 4e10 in complex with a thioether-linked peptide encompassing the 4e10 epitope on gp41

PDB Compounds: (M:) Fab 4E10

SCOPe Domain Sequences for d2fx9m2:

Sequence; same for both SEQRES and ATOM records:

>d2fx9m2 b.1.1.2 (M:108-213) Immunoglobulin light chain kappa constant domain, CL-kappa {Human (Homo sapiens) [TaxId: 9606]}
rtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqd
skdstyslsstltlskadyekhkvyacevthqglsspvtksfnrge

Timeline for d2fx9m2:

• d2fx9m2 first appeared in SCOP 1.73
  
• d2fx9m2 appears in SCOPe 2.04
  
• d2fx9m2 appears in SCOPe 2.06
  
• d2fx9m2 appears in the current release, SCOPe 2.08