SCOPe 2.03: Domain d2fund1: 2fun D:3222-3477

Lineage for d2fund1 (2fun D:3222-3477)

1. Root: SCOPe 2.03

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.17: Caspase-like [52128] (1 superfamily)
   3 layers, a/b/a; core: mixed beta-sheet of 6 strands, order 213456, strand 6 is antiparallel to the rest

4. Superfamily c.17.1: Caspase-like [52129] (3 families)
   mature protein may be composed of two chains folded in a single domain

5. Family c.17.1.1: Caspase catalytic domain [52130] (8 proteins)

6. Protein Caspase-8 [52135] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [52136] (6 PDB entries)

8. Domain d2fund1: 2fun D:3222-3477 [134183]
   Other proteins in same PDB: d2funa1, d2func1
   automatically matched to d1i4eb_

Details for d2fund1

PDB Entry: 2fun, 3 Å

PDB Description: alternative p35-caspase-8 complex

PDB Compounds: (D:) caspase-8

SCOPe Domain Sequences for d2fund1:

Sequence, based on SEQRES records:

>d2fund1 c.17.1.1 (D:3222-3477) Caspase-8 {Human (Homo sapiens) [TaxId: 9606]}
ldkvyqmkskprgycliinnhnfakarekvpklhsirdrngthldagaltttfeelhfei
kphhdctveqiyeilkiyqlmdhsnmdcficcilshgdkgiiygtdgqeapiyeltsqft
glkcpslagkpkvffiqacqgdnyqkgipvetdseeqpylemdlsspqtryipdeadfll
gmatvnncvsyrnpaegtwyiqslcqslrercprgddiltiltevnyevsnkddkknmgk
qmpqptftlrkklvfp

Sequence, based on observed residues (ATOM records):

>d2fund1 c.17.1.1 (D:3222-3477) Caspase-8 {Human (Homo sapiens) [TaxId: 9606]}
ldkvyqmkskprgycliinnhnfakarekvpklhsirdrngthldagaltttfeelhfei
kphhdctveqiyeilkiyqlmdhsnmdcficcilshgdkgiiygtdgqeapiyeltsqft
glkcpslagkpkvffiqacqgdnyqkgipvetdtryipdeadfllgmatvnncvsyrnpa
egtwyiqslcqslrercprgddiltiltevnyevsnkddkknmgkqmpqptftlrkklvf
p

Timeline for d2fund1:

• d2fund1 first appeared in SCOP 1.73
  
• d2fund1 appears in SCOPe 2.02
  
• d2fund1 is called d2fund_ in SCOPe 2.04
  
• d2fund1 appears in the current release, SCOPe 2.08, called d2fund_