SCOPe 2.08: Domain d2fund_: 2fun D:

Lineage for d2fund_ (2fun D:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.17: Caspase-like [52128] (1 superfamily)
   3 layers, a/b/a; core: mixed beta-sheet of 6 strands, order 213456, strand 6 is antiparallel to the rest

4. Superfamily c.17.1: Caspase-like [52129] (3 families)
   mature protein may be composed of two chains folded in a single domain

5. Family c.17.1.1: Caspase catalytic domain [52130] (8 proteins)

6. Protein Caspase-8 [52135] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [52136] (8 PDB entries)

8. Domain d2fund_: 2fun D: [134183]
   Other proteins in same PDB: d2funa_, d2func_
   automated match to d2funb1

Details for d2fund_

PDB Entry: 2fun, 3 Å

PDB Description: alternative p35-caspase-8 complex

PDB Compounds: (D:) caspase-8

SCOPe Domain Sequences for d2fund_:

Sequence, based on SEQRES records:

>d2fund_ c.17.1.1 (D:) Caspase-8 {Human (Homo sapiens) [TaxId: 9606]}
ldkvyqmkskprgycliinnhnfakarekvpklhsirdrngthldagaltttfeelhfei
kphhdctveqiyeilkiyqlmdhsnmdcficcilshgdkgiiygtdgqeapiyeltsqft
glkcpslagkpkvffiqacqgdnyqkgipvetdseeqpylemdlsspqtryipdeadfll
gmatvnncvsyrnpaegtwyiqslcqslrercprgddiltiltevnyevsnkddkknmgk
qmpqptftlrkklvfp

Sequence, based on observed residues (ATOM records):

>d2fund_ c.17.1.1 (D:) Caspase-8 {Human (Homo sapiens) [TaxId: 9606]}
ldkvyqmkskprgycliinnhnfakarekvpklhsirdrngthldagaltttfeelhfei
kphhdctveqiyeilkiyqlmdhsnmdcficcilshgdkgiiygtdgqeapiyeltsqft
glkcpslagkpkvffiqacqgdnyqkgipvetdtryipdeadfllgmatvnncvsyrnpa
egtwyiqslcqslrercprgddiltiltevnyevsnkddkknmgkqmpqptftlrkklvf
p

Timeline for d2fund_:

• d2fund_ first appeared in SCOP 1.73, called d2fund1
  
• d2fund_ appears in SCOPe 2.07