SCOP 1.73: Domain d2fgba1: 2fgb A:5-321

Lineage for d2fgba1 (2fgb A:5-321)

1. Root: SCOP 1.73

2. Class c: Alpha and beta proteins (a/b) [51349] (141 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.7: NAD(P)-linked oxidoreductase [51430] (1 family)

5. Family c.1.7.1: Aldo-keto reductases (NADP) [51431] (15 proteins)
   Common fold covers whole protein structure

6. Protein Prostaglandin d2 11-ketoreductase (akr1c3) [102051] (1 species)
   Aldo-keto reductase family 1 member c3

7. Species Human (Homo sapiens) [TaxId:9606] [102052] (10 PDB entries)

8. Domain d2fgba1: 2fgb A:5-321 [133427]
   automatically matched to d1ry0a_
   complexed with act, nap, p6g

Details for d2fgba1

PDB Entry: 2fgb, 1.35 Å

PDB Description: Crystal structure of human 17bet a-hydroxysteroid dehydrogenase type 5 in complexes with PEG and NADP

PDB Compounds: (A:) Aldo-keto reductase family 1 member C3

SCOP Domain Sequences for d2fgba1:

Sequence, based on SEQRES records:

>d2fgba1 c.1.7.1 (A:5-321) Prostaglandin d2 11-ketoreductase (akr1c3) {Human (Homo sapiens) [TaxId: 9606]}
qqcvklndghfmpvlgfgtyappevprskalevtklaieagfrhidsahlynneeqvgla
irskiadgsvkredifytsklwstfhrpelvrpalenslkkaqldyvdlylihspmslkp
geelsptdengkvifdivdlcttweamekckdaglaksigvsnfnrrqlemilnkpglky
kpvcnqvechpyfnrsklldfckskdivlvaysalgsqrdkrwvdpnspvlledpvlcal
akkhkrtpalialryqlqrgvvvlaksyneqrirqnvqvfefqltaedmkaidgldrnlh
yfnsdsfashpnypysd

Sequence, based on observed residues (ATOM records):

>d2fgba1 c.1.7.1 (A:5-321) Prostaglandin d2 11-ketoreductase (akr1c3) {Human (Homo sapiens) [TaxId: 9606]}
qqcvklndghfmpvlgfgtyappevprskalevtklaieagfrhidsahlynneeqvgla
irskiadgsvkredifytsklwstfhrpelvrpalenslkkaqldyvdlylihspmslkp
geifdivdlcttweamekckdaglaksigvsnfnrrqlemilnkpglkykpvcnqvechp
yfnrsklldfckskdivlvaysalgsqrdkrwvdpnspvlledpvlcalakkhkrtpali
alryqlqrgvvvlaksyneqrirqnvqvfefqltaedmkaidgldrnlhyfnsdsfashp
nypysd

Timeline for d2fgba1:

• d2fgba1 is new in SCOP 1.73
  
• d2fgba1 appears in SCOP 1.75
  
• d2fgba1 appears in the current release, SCOPe 2.08, called d2fgba_