SCOPe 2.08: Domain d2eufb_: 2euf B:

Lineage for d2eufb_ (2euf B:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cyclin-dependent PK, CDK6 [88859] (1 species)
   CMGC group; CDKs subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [88860] (16 PDB entries)

8. Domain d2eufb_: 2euf B: [132386]
   Other proteins in same PDB: d2eufa1, d2eufa2
   automated match to d1blxa_
   complexed with act, ca, dms, lqq

Details for d2eufb_

PDB Entry: 2euf, 3 Å

PDB Description: X-ray structure of human CDK6-Vcyclin in complex with the inhibitor PD0332991

PDB Compounds: (B:) cell division protein kinase 6

SCOPe Domain Sequences for d2eufb_:

Sequence, based on SEQRES records:

>d2eufb_ d.144.1.7 (B:) Cyclin-dependent PK, CDK6 {Human (Homo sapiens) [TaxId: 9606]}
dqqyecvaeigegaygkvfkardlknggrfvalkrvrvqtgeegmplstirevavlrhle
tfehpnvvrlfdvctvsrtdretkltlvfehvdqdlttyldkvpepgvptetikdmmfql
lrgldflhshrvvhrdlkpqnilvtssgqikladfglariysfqmaltsvvvtlwyrape
vllqssyatpvdlwsvgcifaemfrrkplfrgssdvdqlgkildviglpgeedwprdval
prqafhsksaqpiekfvtdidelgkdlllkcltfnpakrisaysalshpyfqdler

Sequence, based on observed residues (ATOM records):

>d2eufb_ d.144.1.7 (B:) Cyclin-dependent PK, CDK6 {Human (Homo sapiens) [TaxId: 9606]}
dqqyecvaeigegaygkvfkardlknggrfvalkrvrvqtgeegmplstirevavlrhle
tfehpnvvrlfdvctvsrtdretkltlvfehvdqdlttyldkvpepgvptetikdmmfql
lrgldflhshrvvhrdlkpqnilvtssgqikladfglariysfqmaltsvvvtlwyrape
vllqssyatpvdlwsvgcifaemfrrkplfrgssdvdqlgkildviglpgeedwpaqpie
kfvtdidelgkdlllkcltfnpakrisaysalshpyfqdler

Timeline for d2eufb_:

• d2eufb_ first appeared in SCOP 1.73, called d2eufb1
  
• d2eufb_ appears in SCOPe 2.07