SCOPe 2.08: Domain d2duxa_: 2dux A:

Lineage for d2duxa_ (2dux A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (34 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.7: NAD(P)-linked oxidoreductase [51430] (2 families)

5. Family c.1.7.1: Aldo-keto reductases (NADP) [51431] (16 proteins)
   Common fold covers whole protein structure

6. Protein automated matches [190169] (7 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188399] (46 PDB entries)

8. Domain d2duxa_: 2dux A: [131753]
   automated match to d1pwla_
   complexed with nap, zst

Details for d2duxa_

PDB Entry: 2dux, 1.6 Å

PDB Description: Crystal structure of human Aldose Reductase complexed with zopolrestat after 3 days soaking (3days_soaked_1)

PDB Compounds: (A:) aldose reductase

SCOPe Domain Sequences for d2duxa_:

Sequence; same for both SEQRES and ATOM records:

>d2duxa_ c.1.7.1 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
asrillnngakmpilglgtwksppgqvteavkvaidvgyrhidcahvyqnenevgvaiqe
klreqvvkreelfivsklwctyhekglvkgacqktlsdlkldyldlylihwptgfkpgke
ffpldesgnvvpsdtnildtwaameelvdeglvkaigisnfnhlqvemilnkpglkykpa
vnqiechpyltqekliqycqskgivvtaysplgspdrpwakpedpslledprikaiaakh
nkttaqvlirfpmqrnlvvipksvtperiaenfkvfdfelssqdmttllsynrnwrvcal
lsctshkdypfheef

Timeline for d2duxa_:

• d2duxa_ first appeared in SCOP 1.73, called d2duxa1
  
• d2duxa_ appears in SCOPe 2.07