SCOPe 2.06: Domain d2cgna_: 2cgn A:

Lineage for d2cgna_ (2cgn A:)

1. Root: SCOPe 2.06

2. Class b: All beta proteins [48724] (177 folds)

3. Fold b.82: Double-stranded beta-helix [51181] (7 superfamilies)
   one turn of helix is made by two pairs of antiparallel strands linked with short turns
   has appearance of a sandwich of distinct architecture and jelly-roll topology

4. Superfamily b.82.2: Clavaminate synthase-like [51197] (16 families)
   Iron and ketoglutarate-dependent enzymes; elaborated version of this common fold

5. Family b.82.2.6: Hypoxia-inducible factor HIF ihhibitor (FIH1) [82194] (1 protein)

6. Protein Hypoxia-inducible factor HIF ihhibitor (FIH1) [82195] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [82196] (34 PDB entries)

8. Domain d2cgna_: 2cgn A: [130426]
   automated match to d1iz3a_
   complexed with fe, sin, so4

Details for d2cgna_

PDB Entry: 2cgn, 2.4 Å

PDB Description: factor inhibiting hif-1 alpha with succinate

PDB Compounds: (A:) hypoxia-inducible factor 1 alpha inhibitor

SCOPe Domain Sequences for d2cgna_:

Sequence, based on SEQRES records:

>d2cgna_ b.82.2.6 (A:) Hypoxia-inducible factor HIF ihhibitor (FIH1) {Human (Homo sapiens) [TaxId: 9606]}
ataaeavasgsgepreeagalgpawdesqlrsysfptrpiprlsqsdpraeelieneepv
vltdtnlvypalkwdleylqenigngdfsvysasthkflyydekkmanfqnfkprsnree
mkfhefveklqdiqqrggeerlylqqtlndtvgrkivmdflgfnwnwinkqqgkrgwgql
tsnllligmegnvtpahydeqqnffaqikgykrcilfppdqfeclypypvhhpcdrqsqv
dfdnpdyerfpnfqnvvgyetvvgpgdvlyipmywwhhiesllnggititvnfwykgapt
pkrieyplkahqkvaimrniekmlgealgnpqevgpllntmikgryn

Sequence, based on observed residues (ATOM records):

>d2cgna_ b.82.2.6 (A:) Hypoxia-inducible factor HIF ihhibitor (FIH1) {Human (Homo sapiens) [TaxId: 9606]}
ataaeavasgsgepreeagalgpawdesqlrsysfptrpiprlsqsdpraeelieneepv
vltdtnlvypalkwdleylqenigngdfsvysasthkflyydekkmanfnreemkfhefv
eklqdiqqreerlylqqtlndtvgrkivmdflgfnwnwinkqqgkrgwgqltsnllligm
egnvtpahydeqqnffaqikgykrcilfppdqfeclypypvhhpcdrqsqvdfdnpdyer
fpnfqnvvgyetvvgpgdvlyipmywwhhiesllnggititvnfwykgaptpkrieyplk
ahqkvaimrniekmlgealgnpqevgpllntmikgryn

Timeline for d2cgna_:

• d2cgna_ first appeared in SCOP 1.73, called d2cgna1
  
• d2cgna_ appears in SCOPe 2.05
  
• d2cgna_ appears in SCOPe 2.07
  
• d2cgna_ appears in the current release, SCOPe 2.08