SCOPe 2.03: Domain d2brha1: 2brh A:6-271

Lineage for d2brha1 (2brh A:6-271)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cell cycle checkpoint kinase chk1 [64404] (1 species)
   CaMK group; CAMKL subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [64405] (70 PDB entries)

8. Domain d2brha1: 2brh A:6-271 [128998]
   automatically matched to d1ia8a_
   complexed with dfw

Details for d2brha1

PDB Entry: 2brh, 2.1 Å

PDB Description: structure-based design of novel chk1 inhibitors: insights into hydrogen bonding and protein-ligand affinity

PDB Compounds: (A:) Serine/threonine-protein kinase Chk1

SCOPe Domain Sequences for d2brha1:

Sequence, based on SEQRES records:

>d2brha1 d.144.1.7 (A:6-271) Cell cycle checkpoint kinase chk1 {Human (Homo sapiens) [TaxId: 9606]}
vedwdlvqtlgegaygevqlavnrvteeavavkivdmkravdcpenikkeicinkmlnhe
nvvkfyghrregniqylfleycsggelfdriepdigmpepdaqrffhqlmagvvylhgig
ithrdikpenlllderdnlkisdfglatvfrynnrerllnkmcgtlpyvapellkrrefh
aepvdvwscgivltamlagelpwdqpsdscqeysdwkekktylnpwkkidsaplallhki
lvenpsaritipdikkdrwynkplkk

Sequence, based on observed residues (ATOM records):

>d2brha1 d.144.1.7 (A:6-271) Cell cycle checkpoint kinase chk1 {Human (Homo sapiens) [TaxId: 9606]}
vedwdlvqtlgegaygevqlavnrvteeavavkivdnikkeicinkmlnhenvvkfyghr
regniqylfleycsggelfdriepdigmpepdaqrffhqlmagvvylhgigithrdikpe
nlllderdnlkisdfglatvfrynnrerllnkmcgtlpyvapellkrrefhaepvdvwsc
givltamlagelpwdqpsdscqeysdwkekktylnpwkkidsaplallhkilvenpsari
tipdikkdrwynkplkk

Timeline for d2brha1:

• d2brha1 first appeared in SCOP 1.73
  
• d2brha1 appears in SCOPe 2.02
  
• d2brha1 is called d2brha_ in SCOPe 2.04
  
• d2brha1 appears in the current release, SCOPe 2.08, called d2brha_