SCOP 1.73: Domain d2brga1: 2brg A:7-269

Lineage for d2brga1 (2brg A:7-269)

1. Root: SCOP 1.73

2. Class d: Alpha and beta proteins (a+b) [53931] (334 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (7 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (61 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cell cycle checkpoint kinase chk1 [64404] (1 species)
   CaMK group; CAMKL subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [64405] (27 PDB entries)

8. Domain d2brga1: 2brg A:7-269 [128997]
   automatically matched to d1ia8a_
   complexed with dfy

Details for d2brga1

PDB Entry: 2brg, 2.1 Å

PDB Description: structure-based design of novel chk1 inhibitors: insights into hydrogen bonding and protein-ligand affinity

PDB Compounds: (A:) Serine/threonine-protein kinase Chk1

SCOP Domain Sequences for d2brga1:

Sequence, based on SEQRES records:

>d2brga1 d.144.1.7 (A:7-269) Cell cycle checkpoint kinase chk1 {Human (Homo sapiens) [TaxId: 9606]}
edwdlvqtlgegaygevqlavnrvteeavavkivdmkravdcpenikkeicinkmlnhen
vvkfyghrregniqylfleycsggelfdriepdigmpepdaqrffhqlmagvvylhgigi
thrdikpenlllderdnlkisdfglatvfrynnrerllnkmcgtlpyvapellkrrefha
epvdvwscgivltamlagelpwdqpsdscqeysdwkekktylnpwkkidsaplallhkil
venpsaritipdikkdrwynkpl

Sequence, based on observed residues (ATOM records):

>d2brga1 d.144.1.7 (A:7-269) Cell cycle checkpoint kinase chk1 {Human (Homo sapiens) [TaxId: 9606]}
edwdlvqtlgegaygevqlavnrvteeavavkivdmkenikkeicinkmlnhenvvkfyg
hrregniqylfleycsggelfdriepdigmpepdaqrffhqlmagvvylhgigithrdik
penlllderdnlkisdfglatvfrynnrerllnkmcgtlpyvapellkrrefhaepvdvw
scgivltamlagelpwdqpsdscqeysdwkekktylnpwkkidsaplallhkilvenpsa
ritipdikkdrwynkpl

Timeline for d2brga1:

• d2brga1 is new in SCOP 1.73
  
• d2brga1 appears in SCOP 1.75
  
• d2brga1 appears in the current release, SCOPe 2.08, called d2brga_