SCOPe 2.08: Domain d2brga_: 2brg A:

Lineage for d2brga_ (2brg A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (20 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (850 PDB entries)

8. Domain d2brga_: 2brg A: [128997]
   automated match to d3nlba_
   complexed with dfy

Details for d2brga_

PDB Entry: 2brg, 2.1 Å

PDB Description: structure-based design of novel chk1 inhibitors: insights into hydrogen bonding and protein-ligand affinity

PDB Compounds: (A:) Serine/threonine-protein kinase Chk1

SCOPe Domain Sequences for d2brga_:

Sequence, based on SEQRES records:

>d2brga_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
edwdlvqtlgegaygevqlavnrvteeavavkivdmkravdcpenikkeicinkmlnhen
vvkfyghrregniqylfleycsggelfdriepdigmpepdaqrffhqlmagvvylhgigi
thrdikpenlllderdnlkisdfglatvfrynnrerllnkmcgtlpyvapellkrrefha
epvdvwscgivltamlagelpwdqpsdscqeysdwkekktylnpwkkidsaplallhkil
venpsaritipdikkdrwynkpl

Sequence, based on observed residues (ATOM records):

>d2brga_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
edwdlvqtlgegaygevqlavnrvteeavavkivdmkenikkeicinkmlnhenvvkfyg
hrregniqylfleycsggelfdriepdigmpepdaqrffhqlmagvvylhgigithrdik
penlllderdnlkisdfglatvfrynnrerllnkmcgtlpyvapellkrrefhaepvdvw
scgivltamlagelpwdqpsdscqeysdwkekktylnpwkkidsaplallhkilvenpsa
ritipdikkdrwynkpl

Timeline for d2brga_:

• d2brga_ first appeared in SCOP 1.73, called d2brga1
  
• d2brga_ appears in SCOPe 2.07