Class c: Alpha and beta proteins (a/b) [51349] (148 folds) |
Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily) 3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465 |
Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families) there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules |
Family c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module [88741] (5 proteins) parent family to TK and PFOR heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module automatically mapped to Pfam PF02779 |
Protein Branched-chain alpha-keto acid dehydrogenase, Pyr module [88742] (2 species) |
Species Human (Homo sapiens) [TaxId:9606] [88743] (23 PDB entries) Uniprot P21953 52-392 |
Domain d2bffb1: 2bff B:2-204 [128421] Other proteins in same PDB: d2bffa1, d2bffb2 automated match to d1v16b1 complexed with gol, k, mn, tzd |
PDB Entry: 2bff (more details), 1.46 Å
SCOPe Domain Sequences for d2bffb1:
Sequence, based on SEQRES records: (download)
>d2bffb1 c.36.1.7 (B:2-204) Branched-chain alpha-keto acid dehydrogenase, Pyr module {Human (Homo sapiens) [TaxId: 9606]} ahftfqpdpepreygqtqkmnlfqsvtsaldnslakdptavifgedvafggvfrctvglr dkygkdrvfntplceqgivgfgigiavtgataiaeiqfadyifpafdqivneaakyryrs gdlfncgsltirspwgcvghgalyhsqspeaffahcpgikvviprspfqakglllscied knpciffepkilyraaaeevpie
>d2bffb1 c.36.1.7 (B:2-204) Branched-chain alpha-keto acid dehydrogenase, Pyr module {Human (Homo sapiens) [TaxId: 9606]} ahfeygqtqkmnlfqsvtsaldnslakdptavifgedvafggvfrctvglrdkygkdrvf ntplceqgivgfgigiavtgataiaeiqfadyifpafdqivneaakyryrsgdlfncgsl tirspwgcvghgalyhsqspeaffahcpgikvviprspfqakglllsciedknpciffep kilyraaaeevpie
Timeline for d2bffb1: