SCOPe 2.08: Domain d2ayna1: 2ayn A:100-482

Lineage for d2ayna1 (2ayn A:100-482)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.3: Cysteine proteinases [54000] (1 superfamily)
   consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn

4. Superfamily d.3.1: Cysteine proteinases [54001] (24 families)
   the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet

5. Family d.3.1.9: Ubiquitin carboxyl-terminal hydrolase, UCH [82568] (6 proteins)
   Pfam PF00443

6. Protein Ubiquitin carboxyl-terminal hydrolase 14 [142860] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [142861] (7 PDB entries)
   Uniprot P54578 100-482

8. Domain d2ayna1: 2ayn A:100-482 [127563]

Details for d2ayna1

PDB Entry: 2ayn, 3.2 Å

PDB Description: Structure of USP14, a proteasome-associated deubiquitinating enzyme

PDB Compounds: (A:) Ubiquitin carboxyl-terminal hydrolase 14

SCOPe Domain Sequences for d2ayna1:

Sequence, based on SEQRES records:

>d2ayna1 d.3.1.9 (A:100-482) Ubiquitin carboxyl-terminal hydrolase 14 {Human (Homo sapiens) [TaxId: 9606]}
melpcgltnlgntcymnatvqcirsvpelkdalkryagalrasgemasaqyitaalrdlf
dsmdktsssippiillqflhmafpqfaekgeqgqylqqdanecwiqmmrvlqqkleaied
dsvketdsssasaatpskkkslidqffgvefettmkcteseeeevtkgkenqlqlscfin
qevkylftglklrlqeeitkqsptlqrnalyiksskisrlpayltiqmvrffykekesvn
akvlkdvkfplmldmyelctpelqekmvsfrskfkdledkkvnqqpntsdkksspqkevk
yepfsfaddigsnncgyydlqavlthqgrssssghyvswvkrkqdewikfdddkvsivtp
edilrlsgggdwhiayvllygpr

Sequence, based on observed residues (ATOM records):

>d2ayna1 d.3.1.9 (A:100-482) Ubiquitin carboxyl-terminal hydrolase 14 {Human (Homo sapiens) [TaxId: 9606]}
melpcgltnlgntcymnatvqcirsvpelkdalkryagalasaqyitaalrdlfdsmdkt
sssippiillqflhmafpqfaekgeqgqylqqdanecwiqmmrvlqqkleaieddkslid
qffgvefettmkcteseeeevtkgkenqlqlscfinqevkylftglklrlqeeitkqspt
lqrnalyiksskisrlpayltiqmvrffykekesvnakvlkdvkfplmldmyelctpelq
ekmvsfrskfkdledepfsfaddigsnncgyydlqavlthqgrssssghyvswvkrkqde
wikfdddkvsivtpedilrlsgggdwhiayvllygpr

Timeline for d2ayna1:

• d2ayna1 first appeared in SCOP 1.73
  
• d2ayna1 appears in SCOPe 2.07