SCOPe 2.05: Domain d2aw1a_: 2aw1 A:

Lineage for d2aw1a_ (2aw1 A:)

1. Root: SCOPe 2.05

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.74: Carbonic anhydrase [51068] (1 superfamily)
   single sheet; 10 strands

4. Superfamily b.74.1: Carbonic anhydrase [51069] (2 families)

5. Family b.74.1.1: Carbonic anhydrase [51070] (2 proteins)
   automatically mapped to Pfam PF00194

6. Protein Carbonic anhydrase [51071] (10 species)

7. Species Human (Homo sapiens), erythrocytes, isozyme II [TaxId:9606] [51073] (555 PDB entries)
   Uniprot P00918

8. Domain d2aw1a_: 2aw1 A: [127388]
   automated match to d1can__
   complexed with cox, gol, hgb, zn

Details for d2aw1a_

PDB Entry: 2aw1, 1.46 Å

PDB Description: Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II "selective" inhibitor Celecoxib

PDB Compounds: (A:) carbonic anhydrase II

SCOPe Domain Sequences for d2aw1a_:

Sequence; same for both SEQRES and ATOM records:

>d2aw1a_ b.74.1.1 (A:) Carbonic anhydrase {Human (Homo sapiens), erythrocytes, isozyme II [TaxId: 9606]}
hhwgygkhngpehwhkdfpiakgerqspvdidthtakydpslkplsvsydqatslrilnn
ghafnvefddsqdkavlkggpldgtyrliqfhfhwgsldgqgsehtvdkkkyaaelhlvh
wntkygdfgkavqqpdglavlgiflkvgsakpglqkvvdvldsiktkgksadftnfdprg
llpesldywtypgslttppllecvtwivlkepisvsseqvlkfrklnfngegepeelmvd
nwrpaqplknrqikasf

Timeline for d2aw1a_:

• d2aw1a_ first appeared in SCOP 1.73, called d2aw1a1
  
• d2aw1a_ appears in SCOPe 2.04
  
• d2aw1a_ appears in SCOPe 2.06
  
• d2aw1a_ appears in the current release, SCOPe 2.08