SCOPe 2.01: Domain d2aeih_: 2aei H:

Lineage for d2aeih_ (2aei H:)

1. Root: SCOPe 2.01

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families)

5. Family b.47.1.2: Eukaryotic proteases [50514] (48 proteins)

6. Protein Coagulation factor VIIa [50550] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50551] (28 PDB entries)
   Uniprot P08709 213-466 ! Uniprot P08709 213-446

8. Domain d2aeih_: 2aei H: [126631]
   Other proteins in same PDB: d2aeil1, d2aeil2, d2aeil3, d2aeit1, d2aeit2
   automated match to d1cvwh_
   complexed with 03r, ca, cac

Details for d2aeih_

PDB Entry: 2aei, 2.52 Å

PDB Description: Crystal structure of a ternary complex of factor VIIa/tissue factor and 2-[[6-[3-(aminoiminomethyl)phenoxy]-3,5-difluro-4-[(1-methyl-3-phenylpropyl)amino]-2-pyridinyl]oxy]-benzoic acid

PDB Compounds: (H:) Coagulation factor VII

SCOPe Domain Sequences for d2aeih_:

Sequence; same for both SEQRES and ATOM records:

>d2aeih_ b.47.1.2 (H:) Coagulation factor VIIa {Human (Homo sapiens) [TaxId: 9606]}
ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdclqqsrkvgdspniteymfcagy
sdgskdsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmr
seprpgvllrapfp

Timeline for d2aeih_:

• d2aeih_ first appeared in SCOP 1.73, called d2aeih1
  
• d2aeih_ was called d2aeih1 in SCOP 1.75
  
• d2aeih_ appears in SCOPe 2.02
  
• d2aeih_ appears in the current release, SCOPe 2.08