SCOPe 2.01: Domain d1yovd_: 1yov D:

Lineage for d1yovd_ (1yov D:)

1. Root: SCOPe 2.01

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.111: Activating enzymes of the ubiquitin-like proteins [69571] (1 superfamily)
   3 layers: a/b/a; mixed beta-sheet of 8 strands, order 32145678; strands 6 and 8 are antiparallel to the rest

4. Superfamily c.111.1: Activating enzymes of the ubiquitin-like proteins [69572] (3 families)
   transfer adenylyl group to the C-terminal carboxyl group of the ubiquitin and MoaD/ThiS-related proteins
   the ATP nucleotide-binding site is similar to that of the NAD-binding Rossmann-folds

5. Family c.111.1.2: Ubiquitin activating enzymes (UBA) [89763] (2 proteins)
   the common fold is elaborated with additional (sub)domains

6. Protein UBA3 [89764] (1 species)
   a subunit of the heterodimeric E1 enzyme for NEDD8; contains an all-alpha insert subdomain of the FF-like fold (residues 210-288) and an extra C-terminal alpha+beta subdomain (partly disordered)

7. Species Human (Homo sapiens) [TaxId:9606] [89765] (8 PDB entries)
   Uniprot Q8TBC4 33-458

8. Domain d1yovd_: 1yov D: [123788]
   Other proteins in same PDB: d1yova_, d1yovc_
   automated match to d1ngvb_
   complexed with zn

Details for d1yovd_

PDB Entry: 1yov, 2.6 Å

PDB Description: Insights into the Ubiquitin Transfer Cascade from the refined structure of the activating enzyme for NEDD8

PDB Compounds: (D:) ubiquitin-activating enzyme E1C

SCOPe Domain Sequences for d1yovd_:

Sequence, based on SEQRES records:

>d1yovd_ c.111.1.2 (D:) UBA3 {Human (Homo sapiens) [TaxId: 9606]}
hvkkflersgpfthpdfepsteslqflldtckvlvigagglgcellknlalsgfrqihvi
dmdtidvsnlnrqflfrpkdigrpkaevaaeflndrvpncnvvphfnkiqdfndtfyrqf
hiivcgldsiiarrwingmlisllnyedgvldpssivplidggtegfkgnarvilpgmta
ciectlelyppqvnfpmctiasmprlpehcieyvrmlqwpkeqpfgegvpldgddpehiq
wifqkslerasqynirgvtyrltqgvvkriipavastnaviaavcatevfkiatsayipl
nnylvfndvdglytytfeaerkencpacsqlpqniqfspsaklqevldyltnsaslqmks
paitatlegknrtlylqsvtsieertrpnlsktlkelglvdgqelavadvttpqtvlf

Sequence, based on observed residues (ATOM records):

>d1yovd_ c.111.1.2 (D:) UBA3 {Human (Homo sapiens) [TaxId: 9606]}
hvkkflersgpfthpdfepsteslqflldtckvlvigagglgcellknlalsgfrqihvi
dmdtidvsnlnrqflfrpkdigrpkaevaaeflndrvpncnvvphfnkiqdfndtfyrqf
hiivcgldsiiarrwingmlisllnyedgvldpssivplidggtegfkgnarvilpgmta
ciectlelyppqvnfpmctiasmprlpehcieyvrmlqwpkeqpfgegvpldgddpehiq
wifqkslerasqynirgvtyrltqgvvkriipavastnaviaavcatevfkiatsayipl
nnylvfndvdglytytfeaerkencpacsqlpqniqlqevldyltnsaslqmkspaitnr
tlylqstsievadvttpqtvlf

Timeline for d1yovd_:

• d1yovd_ first appeared in SCOP 1.73, called d1yovd1
  
• d1yovd_ was called d1yovd1 in SCOP 1.75
  
• d1yovd_ appears in SCOPe 2.02
  
• d1yovd_ appears in the current release, SCOPe 2.08