SCOP 1.75: Domain d1y6kl1: 1y6k L:12-156

Lineage for d1y6kl1 (1y6k L:12-156)

1. Root: SCOP 1.75

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.26: 4-helical cytokines [47265] (1 superfamily)
   core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections

4. Superfamily a.26.1: 4-helical cytokines [47266] (3 families)
   there are two different topoisomers of this fold with different entanglements of the two crossover connections

5. Family a.26.1.3: Interferons/interleukin-10 (IL-10) [47305] (8 proteins)
   contains an additional helix in one of the crossover connections

6. Protein Interleukin-10 (cytokine synthesis inhibitory factor, CSIF) [47306] (3 species)
   intertwined dimer, similar to interferon-gamma

7. Species Human (Homo sapiens) [TaxId:9606] [47307] (7 PDB entries)

8. Domain d1y6kl1: 1y6k L:12-156 [122662]
   Other proteins in same PDB: d1y6kr1, d1y6kr2
   automatically matched to d2ilk__
   mutant

Details for d1y6kl1

PDB Entry: 1y6k, 2.52 Å

PDB Description: crystal structure of human il-10 complexed with the soluble il-10r1 chain

PDB Compounds: (L:) interleukin-10

SCOP Domain Sequences for d1y6kl1:

Sequence; same for both SEQRES and ATOM records:

>d1y6kl1 a.26.1.3 (L:12-156) Interleukin-10 (cytokine synthesis inhibitory factor, CSIF) {Human (Homo sapiens) [TaxId: 9606]}
cthfpgnlpnmlrdlrdafsrvktffqmkdqldnlllkeslledfkgylgcqalsemiqf
yleevmpqaenqdpdikahvnslgenlktlrlrlrrchrflpcenkskaveqvknafnkl
qekgiykamsefdifinyieaymtm

Timeline for d1y6kl1:

• d1y6kl1 first appeared in SCOP 1.73
  
• d1y6kl1 is called d1y6kl_ in SCOPe 2.01
  
• d1y6kl1 appears in the current release, SCOPe 2.08, called d1y6kl_