SCOPe 2.04: Domain d1y2ja_: 1y2j A:

Lineage for d1y2ja_ (1y2j A:)

1. Root: SCOPe 2.04

2. Class a: All alpha proteins [46456] (285 folds)

3. Fold a.211: HD-domain/PDEase-like [109603] (1 superfamily)
   multihelical; consists of two different alpha-helical bundles

4. Superfamily a.211.1: HD-domain/PDEase-like [109604] (6 families)

5. Family a.211.1.2: PDEase [48548] (7 proteins)
   Pfam PF00233; multihelical; can be divided into three subdomains

6. Protein Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b [48549] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48550] (28 PDB entries)
   Uniprot Q07343 324-667

8. Domain d1y2ja_: 1y2j A: [122569]
   automated match to d1xm6a_
   complexed with 7de, mg, zn

Details for d1y2ja_

PDB Entry: 1y2j, 2.55 Å

PDB Description: Catalytic Domain Of Human Phosphodiesterase 4B In Complex With 3,5-dimethyl-1-(3-nitro-phenyl)-1H-pyrazole-4-carboxylic acid ethyl ester

PDB Compounds: (A:) cAMP-specific 3',5'-cyclic phosphodiesterase 4B

SCOPe Domain Sequences for d1y2ja_:

Sequence; same for both SEQRES and ATOM records:

>d1y2ja_ a.211.1.2 (A:) Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b {Human (Homo sapiens) [TaxId: 9606]}
edhlakeledlnkwglnifnvagyshnrpltcimyaifqerdllktfrissdtfitymmt
ledhyhsdvayhnslhaadvaqsthvllstpaldavftdleilaaifaaaihdvdhpgvs
nqflintnselalmyndesvlenhhlavgfkllqeehcdifmnltkkqrqtlrkmvidmv
latdmskhmslladlktmvetkkvtssgvllldnytdriqvlrnmvhcadlsnptkslel
yrqwtdrimeeffqqgdkerergmeispmcdkhtasveksqvgfidyivhplwetwadlv
qpdaqdildtlednrnwyqsmip

Timeline for d1y2ja_:

• d1y2ja_ first appeared in SCOP 1.73, called d1y2ja1
  
• d1y2ja_ appears in SCOPe 2.03
  
• d1y2ja_ appears in SCOPe 2.05
  
• d1y2ja_ appears in the current release, SCOPe 2.08