Lineage for d1xo2b1 (1xo2 B:11-305)

  1. Root: SCOP 1.75
  2. 849709Class d: Alpha and beta proteins (a+b) [53931] (376 folds)
  3. 874255Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 874256Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (7 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 874317Family d.144.1.7: Protein kinases, catalytic subunit [88854] (63 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 874749Protein Cyclin-dependent PK, CDK6 [88859] (1 species)
    CMGC group; CDKs subfamily; serine/threonine kinase
  7. 874750Species Human (Homo sapiens) [TaxId:9606] [88860] (8 PDB entries)
  8. 874756Domain d1xo2b1: 1xo2 B:11-305 [122200]
    Other proteins in same PDB: d1xo2a1, d1xo2a2
    automatically matched to d1blxa_
    complexed with fse

Details for d1xo2b1

PDB Entry: 1xo2 (more details), 2.9 Å

PDB Description: Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin
PDB Compounds: (B:) cell division protein kinase 6

SCOP Domain Sequences for d1xo2b1:

Sequence, based on SEQRES records: (download)

>d1xo2b1 d.144.1.7 (B:11-305) Cyclin-dependent PK, CDK6 {Human (Homo sapiens) [TaxId: 9606]}
qqyecvaeigegaygkvfkardlknggrfvalkrvrvqtgeegmplstirevavlrhlet
fehpnvvrlfdvctvsrtdretkltlvfehvdqdlttyldkvpepgvptetikdmmfqll
rgldflhshrvvhrdlkpqnilvtssgqikladfglariysfqmaltsvvvtlwyrapev
llqssyatpvdlwsvgcifaemfrrkplfrgssdvdqlgkildviglpgeedwprdvalp
rqafhsksaqpiekfvtdidelgkdlllkcltfnpakrisaysalshpyfqdler

Sequence, based on observed residues (ATOM records): (download)

>d1xo2b1 d.144.1.7 (B:11-305) Cyclin-dependent PK, CDK6 {Human (Homo sapiens) [TaxId: 9606]}
qqyecvaeigegaygkvfkardlknggrfvalkrvrvqtgeegmplstirevavlrhlet
fehpnvvrlfdvctvsretkltlvfehvdqdlttyldkvpepgvptetikdmmfqllrgl
dflhshrvvhrdlkpqnilvtssgqikladfglariysfqmaltsvvvtlwyrapevllq
ssyatpvdlwsvgcifaemfrrkplfrgssdvdqlgkildviglpgeedwprdvalprqa
fhaqpiekfvtdidelgkdlllkcltfnpakrisaysalshpyfqdler

SCOP Domain Coordinates for d1xo2b1:

Click to download the PDB-style file with coordinates for d1xo2b1.
(The format of our PDB-style files is described here.)

Timeline for d1xo2b1: