SCOPe 2.03: Domain d1xh8a_: 1xh8 A:

Lineage for d1xh8a_ (1xh8 A:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein cAMP-dependent PK, catalytic subunit [56116] (4 species)
   AGC group; PKA subfamily; serine/threonine kinase

7. Species Cow (Bos taurus) [TaxId:9913] [56118] (39 PDB entries)
   Uniprot P00517

8. Domain d1xh8a_: 1xh8 A: [121999]
   automated match to d1cmke_
   complexed with r55; mutant

Details for d1xh8a_

PDB Entry: 1xh8, 1.6 Å

PDB Description: Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants

PDB Compounds: (A:) cAMP-dependent protein kinase, alpha-catalytic subunit

SCOPe Domain Sequences for d1xh8a_:

Sequence; same for both SEQRES and ATOM records:

>d1xh8a_ d.144.1.7 (A:) cAMP-dependent PK, catalytic subunit {Cow (Bos taurus) [TaxId: 9913]}
qesvkeflakakedflkkwenpaqntahldqferiktlgtgsfgrvmlvkhmetgnhyam
kildkqkvvklkqiehtlnekrilqavnfpflvklefsfkdnsnlymvmeyvpggemfsh
lrrigrfsepharfyaaqivltfeylhsldliyrdlkpenllidqqgyiqvtdfgfakrv
kgrtwtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppffadqpiqiyekiv
sgkvrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfattdwiaiyqrkve
apfipkfkgpgdtsnfddyeeeeirvsinekcgkefsef

Timeline for d1xh8a_:

• d1xh8a_ first appeared in SCOP 1.73, called d1xh8a1
  
• d1xh8a_ appears in SCOPe 2.02
  
• d1xh8a_ appears in SCOPe 2.04
  
• d1xh8a_ appears in the current release, SCOPe 2.08