SCOP 1.75: Protein: Pyruvate dehydrogenase E1-beta, PdhB, N-terminal domain

Lineage for Protein: Pyruvate dehydrogenase E1-beta, PdhB, N-terminal domain

Root: SCOP 1.75
Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465

Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (8 families)

there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules

Family c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module [88741] (4 proteins)
parent family to TK and PFOR
heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module

Protein Pyruvate dehydrogenase E1-beta, PdhB, N-terminal domain [117522] (1 species)

Species:

Bacillus stearothermophilus [TaxId:1422] [117523] (2 PDB entries)
Uniprot P21874
1. Domains for 1w85:
  1. Domain d1w85b1: 1w85 B:1-192 [114336]
    Other proteins in same PDB: d1w85a_, d1w85b2, d1w85c_, d1w85d2, d1w85e_, d1w85f2, d1w85g_, d1w85h2, d1w85i_, d1w85j_
  2. Domain d1w85d1: 1w85 D:1-192 [114339]
    Other proteins in same PDB: d1w85a_, d1w85b2, d1w85c_, d1w85d2, d1w85e_, d1w85f2, d1w85g_, d1w85h2, d1w85i_, d1w85j_
  3. Domain d1w85f1: 1w85 F:1-192 [114342]
    Other proteins in same PDB: d1w85a_, d1w85b2, d1w85c_, d1w85d2, d1w85e_, d1w85f2, d1w85g_, d1w85h2, d1w85i_, d1w85j_
  4. Domain d1w85h1: 1w85 H:1-192 [114345]
    Other proteins in same PDB: d1w85a_, d1w85b2, d1w85c_, d1w85d2, d1w85e_, d1w85f2, d1w85g_, d1w85h2, d1w85i_, d1w85j_
    complexed with k, mg, peg, tdp
2. Domains for 1w88:
  1. Domain d1w88b1: 1w88 B:1-192 [114350]
    Other proteins in same PDB: d1w88a_, d1w88b2, d1w88c_, d1w88d2, d1w88e_, d1w88f2, d1w88g_, d1w88h2, d1w88i_, d1w88j_
  2. Domain d1w88d1: 1w88 D:1-192 [114353]
    Other proteins in same PDB: d1w88a_, d1w88b2, d1w88c_, d1w88d2, d1w88e_, d1w88f2, d1w88g_, d1w88h2, d1w88i_, d1w88j_
  3. Domain d1w88f1: 1w88 F:1-192 [114356]
    Other proteins in same PDB: d1w88a_, d1w88b2, d1w88c_, d1w88d2, d1w88e_, d1w88f2, d1w88g_, d1w88h2, d1w88i_, d1w88j_
  4. Domain d1w88h1: 1w88 H:1-192 [114359]
    Other proteins in same PDB: d1w88a_, d1w88b2, d1w88c_, d1w88d2, d1w88e_, d1w88f2, d1w88g_, d1w88h2, d1w88i_, d1w88j_
    complexed with mg, tdp; mutant

More info for Protein Pyruvate dehydrogenase E1-beta, PdhB, N-terminal domain from c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module

Timeline for Protein Pyruvate dehydrogenase E1-beta, PdhB, N-terminal domain from c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module:

Protein Pyruvate dehydrogenase E1-beta, PdhB, N-terminal domain from c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module first appeared in SCOP 1.71
Protein Pyruvate dehydrogenase E1-beta, PdhB, N-terminal domain from c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module appears in SCOP 1.73
Protein Pyruvate dehydrogenase E1-beta, PdhB, N-terminal domain from c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module appears in SCOPe 2.01
Protein Pyruvate dehydrogenase E1-beta, PdhB, N-terminal domain from c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module appears in the current release, SCOPe 2.08