SCOP 1.71: Protein: 11-beta-hydroxysteroid dehydrogenase 1

Lineage for Protein: 11-beta-hydroxysteroid dehydrogenase 1

Root: SCOP 1.71
Class c: Alpha and beta proteins (a/b) [51349] (134 folds)

Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
The nucleotide-binding modes of this and the next two folds/superfamilies are similar

Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families)

Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (53 proteins)
also known as short-chain dehydrogenases and SDR family
parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

Protein 11-beta-hydroxysteroid dehydrogenase 1 [117423] (2 species)

Species:

Guinea pig (Cavia porcellus) [TaxId:10141] [117425] (1 PDB entry)
- Domains for 1xse:
  1. Domain d1xsea_: 1xse A: [115925]
  2. Domain d1xseb_: 1xse B: [115926]
    complexed with ndp
Human (Homo sapiens) [TaxId:9606] [117424] (3 PDB entries)
1. Domains for 1xu7:
  1. Domain d1xu7a_: 1xu7 A: [116048]
  2. Domain d1xu7b_: 1xu7 B: [116049]
  3. Domain d1xu7c_: 1xu7 C: [116050]
  4. Domain d1xu7d_: 1xu7 D: [116051]
    complexed with cps, ndp; mutant
2. Domains for 1xu9:
  1. Domain d1xu9a_: 1xu9 A: [116052]
  2. Domain d1xu9b_: 1xu9 B: [116053]
  3. Domain d1xu9c_: 1xu9 C: [116054]
  4. Domain d1xu9d_: 1xu9 D: [116055]
    complexed with cps, mes, ndp; mutant
3. Domains for 2bel:
  1. Domain d2bela_: 2bel A: [116694]
  2. Domain d2belb_: 2bel B: [116695]
  3. Domain d2belc_: 2bel C: [116696]
  4. Domain d2beld_: 2bel D: [116697]
    complexed with cbo, cl, nap

More info for Protein 11-beta-hydroxysteroid dehydrogenase 1 from c.2.1.2: Tyrosine-dependent oxidoreductases

Timeline for Protein 11-beta-hydroxysteroid dehydrogenase 1 from c.2.1.2: Tyrosine-dependent oxidoreductases:

Protein 11-beta-hydroxysteroid dehydrogenase 1 from c.2.1.2: Tyrosine-dependent oxidoreductases is new in SCOP 1.71
Protein 11-beta-hydroxysteroid dehydrogenase 1 from c.2.1.2: Tyrosine-dependent oxidoreductases appears in SCOP 1.73
Protein 11-beta-hydroxysteroid dehydrogenase 1 from c.2.1.2: Tyrosine-dependent oxidoreductases appears in the current release, SCOPe 2.08