SCOP 1.73: Domain d2belc_: 2bel C:

Lineage for d2belc_ (2bel C:)

1. Root: SCOP 1.73

2. Class c: Alpha and beta proteins (a/b) [51349] (141 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (70 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein 11-beta-hydroxysteroid dehydrogenase 1 [117423] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [117424] (4 PDB entries)

8. Domain d2belc_: 2bel C: [116696]

Details for d2belc_

PDB Entry: 2bel, 2.11 Å

PDB Description: structure of human 11-beta-hydroxysteroid dehydrogenase in complex with nadp and carbenoxolone

PDB Compounds: (C:) Corticosteroid 11-beta-dehydrogenase isozyme 1

SCOP Domain Sequences for d2belc_:

Sequence, based on SEQRES records:

>d2belc_ c.2.1.2 (C:) 11-beta-hydroxysteroid dehydrogenase 1 {Human (Homo sapiens) [TaxId: 9606]}
grenlyfqghmefrpemlqgkkvivtgaskgigremayhlakmgahvvvtarsketlqkv
vshclelgaasahyiagtmedmtfaeqfvaqagklmggldmlilnhitntslnlfhddih
hvrksmevnflsyvvltvaalpmlkqsngsivvvsslagkvaypmvaaysaskfaldgff
ssirkeysvsrvnvsitlcvlglidtetamkavsgivhmqaapkeecaleiikggalrqe
evyydsslwttllirnp

Sequence, based on observed residues (ATOM records):

>d2belc_ c.2.1.2 (C:) 11-beta-hydroxysteroid dehydrogenase 1 {Human (Homo sapiens) [TaxId: 9606]}
grenlyfqghmefrpemlqgkkvivtgaskgigremayhlakmgahvvvtarsketlqkv
vshclelgaasahyiagtmedmtfaeqfvaqagklmggldmlilnhitntslnlfhddih
hvrksmevnflsyvvltvaalpmlkqsngsivvvsslagkvaypmvaaysaskfaldgff
ssirkeysvsrvnvsitlcvlglidtetamkavsgmqaapkeecaleiikggalrqeevy
ydsslwttllirnp

Timeline for d2belc_:

• d2belc_ first appeared in SCOP 1.71
  
• d2belc_ appears in SCOP 1.75
  
• d2belc_ appears in the current release, SCOPe 2.08, called d2belc1