SCOP 1.73: Domain d1xu9b_: 1xu9 B:

Lineage for d1xu9b_ (1xu9 B:)

1. Root: SCOP 1.73

2. Class c: Alpha and beta proteins (a/b) [51349] (141 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (70 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein 11-beta-hydroxysteroid dehydrogenase 1 [117423] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [117424] (4 PDB entries)

8. Domain d1xu9b_: 1xu9 B: [116053]

Details for d1xu9b_

PDB Entry: 1xu9, 1.55 Å

PDB Description: crystal structure of the interface closed conformation of 11b- hydroxysteroid dehydrogenase isozyme 1

PDB Compounds: (B:) Corticosteroid 11-beta-dehydrogenase, isozyme 1

SCOP Domain Sequences for d1xu9b_:

Sequence; same for both SEQRES and ATOM records:

>d1xu9b_ c.2.1.2 (B:) 11-beta-hydroxysteroid dehydrogenase 1 {Human (Homo sapiens) [TaxId: 9606]}
qqplneefrpemlqgkkvivtgaskgigremayhlakmgahvvvtarsketlqkvvshcl
elgaasahyiagtmedmtfaeqfvaqagklmggldmlilnhitntslnlfhddihhvrks
mevnflsyvvltvaalpmlkqsngsivvvsslagkvaypmvaaysaskfaldgffssirk
eysvsrvnvsitlcvlglidtetamkavsgivhmqaapkeecaleiikggalrqeevyyd
sslwttllirnpsrkileflystsynmdrf

Timeline for d1xu9b_:

• d1xu9b_ first appeared in SCOP 1.71
  
• d1xu9b_ appears in SCOP 1.75
  
• d1xu9b_ appears in the current release, SCOPe 2.08, called d1xu9b1