SCOPe 2.03: Domain d1xtga_: 1xtg A:

Lineage for d1xtga_ (1xtg A:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.92: Zincin-like [55485] (2 superfamilies)
   contains mixed beta sheet with connection over free side of the sheet

4. Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain [55486] (18 families)

5. Family d.92.1.7: Clostridium neurotoxins, catalytic domain [55512] (2 proteins)

6. Protein Botulinum neurotoxin [55513] (4 species)

7. Species Clostridium botulinum, serotype A [TaxId:1491] [55514] (23 PDB entries)
   Uniprot P10845 1-419

8. Domain d1xtga_: 1xtg A: [116020]
   Other proteins in same PDB: d1xtgb_
   complexed with cl, zn

Details for d1xtga_

PDB Entry: 1xtg, 2.1 Å

PDB Description: crystal structure of neurotoxin bont/a complexed with synaptosomal- associated protein 25

PDB Compounds: (A:) Neurotoxin BoNT/A

SCOPe Domain Sequences for d1xtga_:

Sequence; same for both SEQRES and ATOM records:

>d1xtga_ d.92.1.7 (A:) Botulinum neurotoxin {Clostridium botulinum, serotype A [TaxId: 1491]}
pfvnkqfnykdpvngvdiayikipnagqmqpvkafkihnkiwviperdtftnpeegdlnp
ppeakqvpvsyydstylstdnekdnylkgvtklferiystdlgrmlltsivrgipfwggs
tidtelkvidtncinviqpdgsyrseelnlviigpsadiiqfecksfghevlnltrngyg
stqyirfspdftfgfeeslevdtnpllgagkfatdpavtlahqlihaghrlygiainpnr
vfkvntnayyemsglevsfeelrtfgghdakfidslqenefrlyyynkfkdiastlnkak
sivgttaslqymknvfkekyllsedtsgkfsvdklkfdklykmlteiytednfvkffkvl
nrktflnfdkavfkinivpkvnytiydgfnlrntnlaanfngqnteinnmnftklknftp
lvpr

Timeline for d1xtga_:

• d1xtga_ first appeared in SCOP 1.71
  
• d1xtga_ appears in SCOPe 2.02
  
• d1xtga_ appears in SCOPe 2.04
  
• d1xtga_ appears in the current release, SCOPe 2.08, called d1xtga1