SCOP 1.71: Domain d1xosa_: 1xos A:

Lineage for d1xosa_ (1xos A:)

1. Root: SCOP 1.71

2. Class a: All alpha proteins [46456] (226 folds)

3. Fold a.211: HD-domain/PDEase-like [109603] (1 superfamily)
   multihelical; consists of two different alpha-helical bundles

4. Superfamily a.211.1: HD-domain/PDEase-like [109604] (3 families)

5. Family a.211.1.2: PDEase [48548] (6 proteins)
   Pfam 00233; multihelical; can be divided into three subdomains

6. Protein Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b [48549] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48550] (14 PDB entries)

8. Domain d1xosa_: 1xos A: [115712]
   complexed with mg, so4, via, zn

Details for d1xosa_

PDB Entry: 1xos, 2.28 Å

PDB Description: Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Sildenafil

SCOP Domain Sequences for d1xosa_:

Sequence, based on SEQRES records:

>d1xosa_ a.211.1.2 (A:) Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b {Human (Homo sapiens)}
nedhlakeledlnkwglnifnvagyshnrpltcimyaifqerdllktfrissdtfitymm
tledhyhsdvayhnslhaadvaqsthvllstpaldavftdleilaaifaaaihdvdhpgv
snqflintnselalmyndesvlenhhlavgfkllqeehcdifmnltkkqrqtlrkmvidm
vlatdmskhmslladlktmvetkkvtssgvllldnytdriqvlrnmvhcadlsnptksle
lyrqwtdrimeeffqqgdkerergmeispmcdkhtasveksqvgfidyivhplwetwadl
vqpdaqdildtlednrnwyqsmip

Sequence, based on observed residues (ATOM records):

>d1xosa_ a.211.1.2 (A:) Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b {Human (Homo sapiens)}
nedhlakeledlnkwglnifnvagyshnrpltcimyaifqerdllktfrissdtfitymm
tledhyhsdvayhnslhaadvaqsthvllstpaldavftdleilaaifaaaihdvdhpgv
snqflintnselalmyndesvlenhhlavgfkllqeehcdifmnltkkqrqtlrkmvidm
vlatdmskhmslladlktmvetkkvtgvllldnytdriqvlrnmvhcadlsnptkslely
rqwtdrimeeffqqgdkerergmeispmcdkhtasveksqvgfidyivhplwetwadlvq
pdaqdildtlednrnwyqsmip

Timeline for d1xosa_:

• d1xosa_ is new in SCOP 1.71
  
• d1xosa_ appears in SCOP 1.73
  
• d1xosa_ appears in the current release, SCOPe 2.08